Neuro-Oncology Unit, Davidoff Cancer Center, Rabin Medical Center - Beilinson Hospital, Petach Tikva 49100, Address: 39 Jabotinski St, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv Universityl, Address: Ramat Aviv, Tel Aviv 69978, Israel.
Department of Sociology, University of Toronto, Toronto M5S 2J4, Address: 725 Spadina Ave. Toronto, ON, Canada.
J Neurol Sci. 2020 Jan 15;408:116552. doi: 10.1016/j.jns.2019.116552. Epub 2019 Nov 2.
cranial X radiation therapy was the standard of care for treating dermatological conditions until the 1960s, when its association to cancer and particularly high rates of brain tumors was discovered. This study examines associations found between incidence of brain tumor and ethnicity.
This study analyzed two cohorts who underwent examination at age 17 and were followed by linkage to the national cancer registry. The first cohort included 376,336 participants born in 1948-1959 (when treatment with cranial X radiation was standard care for treating tinea capitis), and the second 474,923 participants born in 1960-1971.
In the first cohort, ethnicity was strongly associated with the incidence of brain tumor (BT), with higher incidence observed among patients with origins in North Africa or the Middle East. This effect was ablated in the second cohort, and a significant decrease in the rate of meningiomas was noted.
The association of brain tumor with ethnicity was present only during the period when treatment with cranial X radiation was the standard of care for TC in Israel, therefore it is most likely that radiation exposure was a confounding factor, and that ethnic susceptibility for brain cancer was not causative in these cohorts.
直到 20 世纪 60 年代，颅 X 射线治疗一直是治疗皮肤病的标准治疗方法，当时发现它与癌症，特别是脑瘤的高发率有关。本研究检查了脑瘤发病率与种族之间的关联。
本研究分析了两个队列，他们在 17 岁时接受检查，并通过与国家癌症登记处进行链接进行随访。第一队列包括 1948-1959 年出生的 376336 名参与者（当时颅 X 射线治疗是治疗头癣的标准治疗方法），第二队列包括 1960-1971 年出生的 474923 名参与者。
在第一队列中，种族与脑瘤（BT）的发病率密切相关，来自北非或中东的患者发病率更高。这种影响在第二队列中被消除，脑膜瘤的发病率显著下降。
脑瘤与种族的关联仅存在于颅 X 射线治疗是以色列 TC 标准治疗方法的时期，因此最有可能的是辐射暴露是一个混杂因素，而这些队列中脑瘤的种族易感性不是致病因素。
