Department of Surgery, Hanyang University Medical Center, Seoul, South Korea.
Department of Clinical Nursing, University of Ulsan, Seoul, South Korea.
Eur J Oncol Nurs. 2020 Feb;44:101680. doi: 10.1016/j.ejon.2019.101680. Epub 2019 Nov 1.
Breast cancer patients are more likely to gain than lose weight during chemotherapy. Weight gain due to chemotherapy in breast cancer patients increases the likelihood of complications and the risk of recurrence. The study aimed to investigate changes in weight, body composition, and physical activity in breast cancer patients receiving adjuvant chemotherapy.
This was a prospective longitudinal study. The participants of this study were 37 patients who underwent adjuvant chemotherapy between August 2016 and March 2017 at a University hospital, Seoul, South Korea. We measured weight and body composition using a bioelectrical impedance method, and physical activity through a questionnaire, three times during the study period. The collected data were analyzed using descriptive statistics and repeated measures analysis.
There were no changes in weight, body mass index (BMI), body composition, and physical activity during adjuvant chemotherapy. There were no statistically significant differences in weight and BMI according to clinical characteristics. However, there were significant differences in total body water, muscle mass, and body fat percentage according to menopause status. The changes in physical activity showed no differences according to clinical characteristics.
There was no significant change in weight, body composition, and physical activity during adjuvant chemotherapy in participants with breast cancer. However, total body water, muscle mass, and body fat percentage differed according to menopause status, and body fat percentage appeared to increase rapidly in premenopausal participants following adjuvant chemotherapy. We should pay close attention to the weight of premenopausal women receiving adjuvant chemotherapy.
乳腺癌患者在化疗期间更有可能增加体重而不是减轻体重。乳腺癌患者因化疗而增加的体重会增加并发症的可能性，并增加复发的风险。本研究旨在调查接受辅助化疗的乳腺癌患者的体重、身体成分和身体活动的变化。
这是一项前瞻性纵向研究。本研究的参与者是 2016 年 8 月至 2017 年 3 月在韩国首尔一家大学医院接受辅助化疗的 37 名患者。我们使用生物电阻抗法测量体重和身体成分，并通过问卷三次测量身体活动，在研究期间。使用描述性统计和重复测量分析对收集到的数据进行分析。
在辅助化疗期间，体重、体重指数（BMI）、身体成分和身体活动均无变化。体重和 BMI 与临床特征无统计学差异。然而，绝经状态与总体水、肌肉量和体脂百分比存在显著差异。根据临床特征，身体活动的变化没有差异。
在接受乳腺癌辅助化疗的参与者中，体重、身体成分和身体活动没有明显变化。然而，总体水、肌肉量和体脂百分比因绝经状态而异，并且辅助化疗后绝经前参与者的体脂百分比似乎迅速增加。我们应该密切关注接受辅助化疗的绝经前妇女的体重。
