Department of Radiology, Kastamonu University, 37150 Kastamonu, Turkey.
Department of Radiology, Erzincan University, 24100 Erzincan, Turkey.
Tomography. 2024 Jul 10;10(7):1054-1063. doi: 10.3390/tomography10070079.
Sarcopenia, characterized by progressive skeletal muscle loss, poses significant health risks, including physical impairment and mortality. The relationship between sarcopenia and insulin resistance suggests insulin therapy's potential in preserving muscle mass, particularly in Type 2 diabetes mellitus (T2DM) patients. This study aims to evaluate the Psoas Muscle Index (PMI) via computed tomography (CT) in middle-aged T2DM patients on insulin therapy versus oral antidiabetic drugs (OAD) and controls.
This retrospective study included 107 middle-aged T2DM patients undergoing non-contrast CT scans and 58 age-matched controls. CT images were analyzed to calculate PMI. Statistical analysis included Chi-square tests, independent samples -tests, Mann-Whitney U tests, and correlation analyses.
Insulin-treated patients exhibited higher PMI than OAD users ( < 0.001), while OAD users had lower PMI than controls ( < 0.001). No significant difference was found between insulin-treated patients and controls ( = 0.616). Negative correlations were observed between T2DM duration/age and PMI across all groups, with a positive correlation between T2DM duration and BMI observed in the OAD group.
Insulin therapy in T2DM patients, regardless of age or disease duration, positively impacts muscle mass, highlighting its potential in preserving muscular health and advocating for tailored treatment strategies in T2DM management.
肌少症的特征是骨骼肌进行性丧失，会带来严重的健康风险，包括身体机能受损和死亡。肌少症与胰岛素抵抗之间的关系表明胰岛素治疗可能有助于维持肌肉量，尤其是在 2 型糖尿病（T2DM）患者中。本研究旨在通过计算机断层扫描（CT）评估接受胰岛素治疗与口服降糖药（OAD）治疗和对照组的中年 T2DM 患者的竖脊肌指数（PMI）。
本回顾性研究纳入了 107 名接受非对比 CT 扫描的中年 T2DM 患者和 58 名年龄匹配的对照者。分析 CT 图像以计算 PMI。统计分析包括卡方检验、独立样本 t 检验、Mann-Whitney U 检验和相关性分析。
与 OAD 使用者相比，接受胰岛素治疗的患者的 PMI 更高（<0.001），而 OAD 使用者的 PMI 低于对照组（<0.001）。接受胰岛素治疗的患者与对照组之间无显著差异（=0.616）。在所有组中，T2DM 病程/年龄与 PMI 呈负相关，OAD 组中 T2DM 病程与 BMI 呈正相关。
无论年龄或疾病病程如何，胰岛素治疗均可对 T2DM 患者的肌肉量产生积极影响，这突显了其在维持肌肉健康方面的潜力，并提倡针对 T2DM 管理制定个体化治疗策略。
