Wang Ying, Yan Jianhua, Wen Nachuan, Xiong Hongjie, Cai Shundong, He Qunye, Hu Yaqin, Peng Dongming, Liu Zhenbao, Liu Yanfei
Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, Hunan Province, PR China.
Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, Hunan Province, PR China.
Biomaterials. 2020 Feb;230:119619. doi: 10.1016/j.biomaterials.2019.119619. Epub 2019 Nov 14.
Metal-organic framework (MOF), a novel hybrid porous material which is composited by metal ions and organic linkers, has drawn increasing attention and became a promising material in the biomedical field owing to their unique properties including large pore volume, high surface area, tunable pore size, versatile functionality and high drug loading efficiency. However, the MOF families and members, and the drug release mechanisms in MOF-based stimuli-responsive drug delivery systems (DDSs) are rarely summarized. Here, we systematically classified the families of MOF and introduced some representative members in MOF families. Moreover, the underlying drug release mechanisms were interpreted according to endogenous stimuli (include pH, glutathione (GSH), adenosine-triphosphate (ATP), ion, glucose, enzyme, HS, and etc.) and the exogenous stimuli (include light, temperature, pressure, and etc.). Furthermore, the remaining challenges and future directions of DDSs based on MOF are discussed and proposed. This review revealed the relationship between the structure and properties of MOF. A better understanding of these release mechanisms under different stimuli would benefit the designing of sophisticated DDSs based on the promising material of MOF.
金属有机框架（MOF）是一种由金属离子和有机连接体复合而成的新型混合多孔材料，因其具有独特的性质，包括大孔体积、高比表面积、可调孔径、多功能性和高载药效率，已引起越来越多的关注，并成为生物医学领域中一种有前景的材料。然而，MOF家族及其成员，以及基于MOF的刺激响应药物递送系统（DDS）中的药物释放机制很少被总结。在此，我们系统地对MOF家族进行了分类，并介绍了MOF家族中的一些代表性成员。此外，根据内源性刺激（包括pH值、谷胱甘肽（GSH）、三磷酸腺苷（ATP）、离子、葡萄糖、酶、HS等）和外源性刺激（包括光、温度、压力等）对潜在的药物释放机制进行了解释。此外，还讨论并提出了基于MOF的DDS的剩余挑战和未来方向。这篇综述揭示了MOF的结构与性质之间的关系。更好地理解不同刺激下的这些释放机制将有助于基于有前景的MOF材料设计复杂的DDS。
