Department of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, SE-106 91 Stockholm, Sweden.
Trends Biochem Sci. 2020 Jan;45(1):3-5. doi: 10.1016/j.tibs.2019.10.011. Epub 2019 Nov 19.
Mitochondrial energy conversion involves a chain of membrane-bound proteins that are wired to conduct an electron current, which drives transmembrane proton translocation. These enzymes associate to form supercomplexes, but the functional relevance of the higher-order structures is unknown. A recent study by Letts et al. presents structures of a supercomplex, which suggest how the interaction choreography may control overall functionality.
线粒体能量转换涉及一系列膜结合蛋白，这些蛋白被连接起来以传导电子流，从而驱动跨膜质子转移。这些酶相互结合形成超复合物，但这些高级结构的功能相关性尚不清楚。Letts 等人最近的一项研究提出了一种超复合物的结构，这表明相互作用的编排可能如何控制整体功能。
