HydroSciences Montpellier, Université de Montpellier, CNRS, IRD, Laboratoire d'Ecologie Microbienne Hospitalière, Montpellier University Hospital, France.
Laboratory of Bacteriology, Montpellier University Hospital, France.
J Cyst Fibros. 2020 Jul;19(4):e28-e31. doi: 10.1016/j.jcf.2019.11.004. Epub 2019 Nov 20.
The pathogenic power of Streptococcus pseudopneumoniae has been specified over years, particularly in case of chronic respiratory diseases; S. pseudopneumoniae isolation has however not been characterized before in CF patients. Identification of S. pseudopneumoniae remains challenging due to the high simila-rity level between species of the Streptococcus mitis group. Twenty CF patients with S. pseudopneumoniae were included. Isolates initially identified by phenotypic routine methods were subjected to both recA sequencing and amplification of S. pseudopneumoniae specific markers. Microbiological and clinical data were reviewed for patients with confirmed S. pseudopneumoniae. Thirteen isolates actually belong to S. pseudopneumoniae. S. pseudopneumoniae was associated with pulmonary exacerbation in 46% of the patients, either as the sole pathogen or as part of a polymicrobial infectious process. S. pseudopneumoniae has to be considered as an additional opportunistic pathogen in CF and additional studies are needed to increase knowledge of its epidemiology and clinical significance in CF.
肺炎链球菌的致病性多年来已得到明确，特别是在慢性呼吸道疾病中；然而，在 CF 患者中尚未对肺炎链球菌的分离进行特征描述。由于米氏链球菌组的物种之间具有高度相似性，肺炎链球菌的鉴定仍然具有挑战性。本研究纳入了 20 名患有肺炎链球菌的 CF 患者。最初通过表型常规方法鉴定的分离株均进行 recA 测序和肺炎链球菌特异性标志物的扩增。对确诊为肺炎链球菌的患者进行了微生物学和临床数据的回顾。实际上有 13 株分离物属于肺炎链球菌。肺炎链球菌与 46%的患者的肺部恶化有关，无论是作为单一病原体还是作为多病原体感染过程的一部分。肺炎链球菌在 CF 中被视为一种额外的机会性病原体，需要进一步研究来增加对其流行病学和在 CF 中的临床意义的认识。
