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通过诱导PANC - 1细胞凋亡和细胞周期停滞发挥抗胰腺癌活性。

exerts antipancreatic cancer activity through induction of apoptosis and cell cycle arrest in PANC-1 cells.

作者信息

Kim Ji Hyun, Nam Gi Suk, Kim Sung Hyun, Ryu Deok Seon, Lee Dong Seok

机构信息

Department of Smart Foods and Drugs Graduate School of Inje University Gimhae Korea.

Department of Biomedical Laboratory Science Soonchunhyang University Asan Korea.

出版信息

Food Sci Nutr. 2019 Sep 13;7(11):3549-3559. doi: 10.1002/fsn3.1207. eCollection 2019 Nov.

DOI:10.1002/fsn3.1207
PMID:31763005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6848830/
Abstract

Targeted therapy at the molecular level is important for pancreatic cancer treatment. This study looked over the anticancer activity of in a human pancreatic cancer cell line, PANC-1. An ethyl acetate fraction containing quercetin, kaempferol, and flavonol glycosides from (OJE) exhibited significant anticancer activity against the PANC-1. OJE activated caspase-3, caspase-8, and caspase-9, leading to the induction of both intrinsic and extrinsic apoptosis pathways. It also inhibited cyclin D1, cyclin B1, and cyclin-dependent kinase 4, representing cell cycle arrest at both G1/S and G2/M phases. In addition, OJE phosphorylated MAPKs such as p38, JNK, and ERK, which are important upstream signaling factors in apoptosis and arrest of cell cycle inducing system. In conclusion, OJE effectively exerted antipancreatic cancer activity via induction of apoptosis directed by both intrinsic and extrinsic pathways and arrest of cell cycle regulated at both G1/S and G2/M stages, which is activated by MAPKs, p38, JNK, and ERK.

摘要

分子水平的靶向治疗对胰腺癌治疗至关重要。本研究考察了[具体物质]在人胰腺癌细胞系PANC-1中的抗癌活性。从[具体物质]（OJE）中得到的含有槲皮素、山奈酚和黄酮醇糖苷的乙酸乙酯馏分对PANC-1表现出显著的抗癌活性。OJE激活了半胱天冬酶-3、半胱天冬酶-8和半胱天冬酶-9，导致内源性和外源性凋亡途径均被诱导。它还抑制细胞周期蛋白D1、细胞周期蛋白B1和细胞周期蛋白依赖性激酶4，表现为细胞周期在G1/S和G2/M期均停滞。此外，OJE使丝裂原活化蛋白激酶如p38、JNK和ERK磷酸化，这些是凋亡和细胞周期停滞诱导系统中的重要上游信号因子。总之，OJE通过诱导内源性和外源性途径介导的凋亡以及使由丝裂原活化蛋白激酶p38、JNK和ERK激活的G1/S和G2/M期细胞周期停滞，有效地发挥了抗胰腺癌活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/25d1ff91d768/FSN3-7-3549-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/0b92a64047f6/FSN3-7-3549-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/3f8f0650a092/FSN3-7-3549-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/d49bf6b49cba/FSN3-7-3549-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/a438475e35f3/FSN3-7-3549-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/9568b0f3e160/FSN3-7-3549-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/adce32cb0249/FSN3-7-3549-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/6b882dfb6d9f/FSN3-7-3549-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/2ca547162e26/FSN3-7-3549-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/25d1ff91d768/FSN3-7-3549-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/0b92a64047f6/FSN3-7-3549-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/3f8f0650a092/FSN3-7-3549-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/d49bf6b49cba/FSN3-7-3549-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/a438475e35f3/FSN3-7-3549-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/9568b0f3e160/FSN3-7-3549-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/adce32cb0249/FSN3-7-3549-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/6b882dfb6d9f/FSN3-7-3549-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/2ca547162e26/FSN3-7-3549-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/6848830/25d1ff91d768/FSN3-7-3549-g009.jpg

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