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使用微型切割器的内窥镜鼻窦手术与传统技术的比较研究及其对肺功能测试的影响:一项随机对照试验

Comparative Study Between Endoscopic Sinus Surgery Using Microdebrider and Conventional Techniques with It's Impact on Pulmonary Function Tests: A Randomized Control Trial.

作者信息

Muthubabu K, Gayathri S, Sravanthi P, Thejas Saai Ram, Vinayak R, Srinivasan M K, Rekha Assadi, Sindu M

机构信息

Department of Otorhinolaryngology and Neck and Neck Surgery, Meenakshi Medical College, Hospital and Research Institute, Karaipettai Post, Enathur, Kanchipuram, Tamil Nadu 631552 India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2019 Nov;71(Suppl 3):2127-2132. doi: 10.1007/s12070-018-1565-3. Epub 2019 Mar 29.

Abstract

The nasal airways and their close association to paranasal sinuses are an integral part of the respiratory tract. Mucociliary clearance is the predominant clearance mechanism for both upper and lower airways. The two components of mucociliary clearance are cilia and the secretions above them. It is known that CRS coexists in as many as 40-75% of patients with BA. CRS can present with polyposis or without polyposis. Treatment options for CRS include medical therapy, surgical intervention or both. According to recent guidelines, ESS is the most favourable surgical approach in patients who fail to respond adequately to medical therapy. To assess the extent of improvement in CRS following ESS (either microdebrider or conventional) and if it brings an improvement in the pulmonary function tests. This also assesses symptom scores, endoscopic appearances and CT findings pre-operatively and post-operatively. This study was carried out at the outpatient Department of Otorhinolaryngology and Head and Neck Surgery in Meenakshi Medical College, Hospital and Research Institute, Tamil Nadu. Patients were consented and started on medical treatment with systemic steroids for 2 weeks and topical nasal steroids for 1 month. If the disease persisted after medical therapy, patients were equally randomized into two groups of 30 each-microdebrider and conventional technique. Subjective symptoms of CRS were based on the CRS criteria. Symptoms score were given with Lund-Mckay symptoms scoring, pre-operatively 1 week before and post-operatively 2 months after surgery. Lund-Mckay CT scoring system separately assessed the extent of opacification of sinuses. PFT was assessed using Spirometer (KOKO Legend). There was a statistically considerable difference in the FEV1 values in microdebrider ESS than conventional ESS. Microdebrider ESS is considered superior when we have to address the coexistence of lower airway diseases along with CRS.

摘要

鼻气道及其与鼻窦的紧密联系是呼吸道的一个组成部分。黏液纤毛清除是上、下呼吸道的主要清除机制。黏液纤毛清除的两个组成部分是纤毛及其上方的分泌物。已知在40%-75%的支气管哮喘(BA)患者中并存慢性鼻-鼻窦炎(CRS)。CRS可表现为有息肉或无息肉。CRS的治疗选择包括药物治疗、手术干预或两者结合。根据最近的指南,对于药物治疗反应不佳的患者,内镜鼻窦手术(ESS)是最有利的手术方法。评估ESS(微型切割器或传统方法)后CRS的改善程度,以及它是否能改善肺功能测试。这也评估术前和术后的症状评分、内镜表现和CT结果。本研究在泰米尔纳德邦梅纳克希医学院、医院和研究所的耳鼻喉科及头颈外科门诊进行。患者签署知情同意书后开始接受为期2周的全身用类固醇药物治疗和为期1个月的局部鼻用类固醇药物治疗。如果药物治疗后疾病仍持续存在,患者被平均随机分为两组,每组30人——微型切割器组和传统技术组。CRS的主观症状基于CRS标准。症状评分采用Lund-Mckay症状评分法,术前1周和术后2个月进行。Lund-Mckay CT评分系统分别评估鼻窦浑浊的程度。使用肺活量计(KOKO Legend)评估肺功能测试(PFT)。微型切割器ESS组的第1秒用力呼气容积(FEV1)值与传统ESS组相比有统计学上的显著差异。当必须处理CRS合并下气道疾病时,微型切割器ESS被认为更具优势。

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