Martyn J C, Davidson B E, Studdert M J
School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia.
J Gen Virol. 1990 Nov;71 ( Pt 11):2747-53. doi: 10.1099/0022-1317-71-11-2747.
The nucleotide sequence of feline panleukopenia virus (FPV) strain 193 was determined and compared with the sequence of canine parvovirus (CPV) strain N and partial sequences of FPV strain Carl and CPV strain b. Base differences were identified at 115 positions in these 5.1 kb genomes and predicted amino acid differences occurred at 40 positions. The two overlapping capsid protein genes contained almost twice as many base differences as the single non-structural protein gene (49 compared to 26) and about the same ratio was calculated for predicted amino acid differences (27 compared to 13). The 27 variant amino acids in the capsid proteins were clustered at three sites in the primary sequence, whereas 10 of the 13 variant amino acids in the non-structural protein occurred in the 130 C-terminal amino acids. The two FPV strains differed consistently from the two CPV strains at 31 bases: 12 base changes in the capsid protein genes resulted in six amino acid changes, six base changes in the non-structural protein gene resulted in three amino acid changes, and 13 base changes occurred in the non-coding sequence.
测定了猫泛白细胞减少症病毒（FPV）193株的核苷酸序列，并与犬细小病毒（CPV）N株以及FPV卡尔株和CPV b株的部分序列进行了比较。在这5.1kb的基因组中，在115个位置发现了碱基差异，预计氨基酸差异出现在40个位置。两个重叠的衣壳蛋白基因所含的碱基差异几乎是单个非结构蛋白基因的两倍（分别为49个和26个），预计氨基酸差异的比例也大致相同（分别为27个和13个）。衣壳蛋白中的27个变异氨基酸聚集在一级序列的三个位点，而非结构蛋白中13个变异氨基酸中的10个出现在130个C端氨基酸中。这两株FPV在31个碱基上始终与两株CPV不同：衣壳蛋白基因中的12个碱基变化导致6个氨基酸变化，非结构蛋白基因中的6个碱基变化导致3个氨基酸变化，非编码序列中发生了13个碱基变化。
