布洛芬过量——一项前瞻性研究。
Ibuprofen overdose--a prospective study.
作者信息
Hall A H, Smolinske S C, Kulig K W, Rumack B H
出版信息
West J Med. 1988 Jun;148(6):653-6.
Of 61 cases of ibuprofen overdosage reported consecutively to the Rocky Mountain Poison and Drug Center from September 1985 through April 1986, 16 were excluded because of incomplete follow-up or concurrent medication ingestion. A toxic reaction developed in 7 (16%) of the remaining 45 patients. Nausea, vomiting, abdominal cramps, mild central nervous system depression, coma, tachycardia, apnea, metabolic acidosis with or without respiratory alkalosis, hematemesis, and oliguric renal failure were noted. Two of six adults had a toxic reaction, and one died. Among pediatric patients, 5/39 (13%) had a toxic reaction. Of patients whose ibuprofen ingestion was less than 104 mg per kg, none became ill. All patients in whom the time of ingestion was known (six of seven) and who had a toxic reaction did so within four hours of ingestion. An ibuprofen overdose, although usually benign, can occasionally produce serious toxicity.
1985年9月至1986年4月期间，连续向落基山毒物与药物中心报告了61例布洛芬过量服用病例，其中16例因随访不完整或同时服用其他药物而被排除。其余45例患者中有7例（16%）出现了中毒反应。症状包括恶心、呕吐、腹部绞痛、轻度中枢神经系统抑制、昏迷、心动过速、呼吸暂停、伴有或不伴有呼吸性碱中毒的代谢性酸中毒、呕血和少尿性肾衰竭。6名成年人中有2例出现中毒反应，1例死亡。在儿科患者中，39例中有5例（13%）出现中毒反应。布洛芬摄入量低于每千克104毫克的患者均未发病。所有已知摄入时间（7例中的6例）且出现中毒反应的患者都是在摄入后4小时内出现症状的。布洛芬过量服用虽然通常是良性的，但偶尔也会产生严重毒性。
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