Lee C Y, Finkler A
Arch Pathol Lab Med. 1986 Aug;110(8):747-9.
A male patient ingested a single overdose of ibuprofen (greater than 20 g). The serum ibuprofen levels were 185 mg/L (897 mumol/L) and 51.6 mg/L (250 mumol/L) at ten hours and 67 hours, respectively, after ingestion. There was also an accumulation of metabolites (2-carboxyibuprofen and 2-hydroxyibuprofen) in the plasma. The patient became unresponsive and developed severe metabolic acidosis, acute renal failure, acute liver-cell injury, acute cholestasis, and thrombocytopenia. Although his course was complicated by respiratory failure, hypotension, and upper gastrointestinal tract bleeding, the patient had complete resolution of multiple organ failure.
一名男性患者单次过量服用布洛芬（超过20克）。摄入后10小时和67小时时，血清布洛芬水平分别为185毫克/升（897微摩尔/升）和51.6毫克/升（250微摩尔/升）。血浆中还出现了代谢产物（2-羧基布洛芬和2-羟基布洛芬）的蓄积。患者出现无反应状态，并发展为严重代谢性酸中毒、急性肾衰竭、急性肝细胞损伤、急性胆汁淤积和血小板减少症。尽管其病程因呼吸衰竭、低血压和上消化道出血而复杂化，但该患者的多器官功能衰竭完全得到缓解。
