Perry S J, Streete P J, Volans G N
Hum Toxicol. 1987 Mar;6(2):173-8. doi: 10.1177/096032718700600211.
Experience during 14 years of prescription only use indicates that the non-steroidal anti-inflammatory drug (NSAID) ibuprofen is of low toxicity in acute overdose. In August 1983 ibuprofen was licensed for over-the-counter (OTC) use in the UK and it was recognised that this change could have an impact upon the epidemiology of analgesic overdose in this country. The London centre of the National Poisons Information Service (NPIS) began a new prospective survey of ibuprofen overdose at the time of OTC release. The first 2 years of this survey detected a marked increase in enquiries concerning ibuprofen overdose but there was no evidence to contradict the former claims of low toxicity. The importance of continued monitoring is stressed.
14年仅凭处方使用的经验表明，非甾体抗炎药布洛芬在急性过量服用时毒性较低。1983年8月，布洛芬在英国获得非处方（OTC）使用许可，人们认识到这一变化可能会对该国镇痛药过量使用的流行病学产生影响。国家毒物信息服务中心（NPIS）的伦敦中心在OTC上市时开始了一项关于布洛芬过量服用的新前瞻性调查。这项调查的头两年发现，关于布洛芬过量服用的咨询显著增加，但没有证据反驳此前关于其低毒性的说法。强调了持续监测的重要性。
