Ikryannikova Larisa N, Kurbatov Leonid K, Soond Surinder M, Zamyatnin Andrey A
Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow 119991, Russia.
Institute of Biomedical Chemistry, Pogodinskaya 10, Moscow 119991, Russia.
Antibiotics (Basel). 2019 Nov 21;8(4):230. doi: 10.3390/antibiotics8040230.
In the context of a post-antibiotic era, the phenomenon of microbial allolysis, which is defined as the partial killing of bacterial population induced by other cells of the same species, may take on greater significance. This phenomenon was revealed in some bacterial species such as and , and has been suspected to occur in some other species or genera, such as enterococci. The mechanisms of this phenomenon, as well as its role in the life of microbial populations still form part of ongoing research. Herein, we describe recent developments in allolysis in the context of its practical benefits as a form of cell death that may give rise to developing new strategies for manipulating the life and death of bacterial communities. We highlight how such findings may be viewed with importance and potential within the fields of medicine, biotechnology, and pharmacology.
在后抗生素时代,微生物自溶现象(定义为同一物种的其他细胞诱导细菌群体部分死亡)可能具有更重要的意义。这种现象已在某些细菌物种(如 和 )中被发现,并且怀疑在其他一些物种或属(如肠球菌)中也会发生。这种现象的机制及其在微生物群体生命中的作用仍是正在进行的研究内容。在此,我们描述了自溶现象的最新进展,鉴于其作为一种细胞死亡形式所具有的实际益处,这可能会催生操纵细菌群落生死的新策略。我们强调了这些发现在医学、生物技术和药理学领域如何被视为具有重要意义和潜力。