Wang Jing, Shu Bing, Li Chen-Guang, Xie Xing-Wen, Liang De, Chen Bo-Lai, Lin Xin-Chao, Wei Xu, Wang Liang, Leng Xiang-Yang, Zhou Ying-Jie, Chen Pei-Zhan, Tao Yu-Ren, Zhou Yong, Zhang Yan, Cui Xue-Jun, Lu Sheng, Wang Hui, Shi Qi, Wang Yong-Jun
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China.
BMJ Open. 2019 Nov 24;9(11):e028084. doi: 10.1136/bmjopen-2018-028084.
Osteoporotic fracture is one of the most common causes of disability and a major contributor to medical care costs in many regions of the world. The polymorphisms of genes related to vitamin D metabolism and transportation are associated with variation in bone mineral density and the risk of osteoporosis.
The China Community-based Cohort of Osteoporosis study is an observational, longitudinal, multicentre, prospective cohort study for middle-aged and older permanent residents of China, which has been ongoing in six cities since 2016. Female residents aged 45-80 years old and male residents aged 50-80 years old are identified through permanent resident lists. All the enrolled participants will complete questionnaires on their personal characteristics and histories. The bone mineral density of their lumbar vertebrae and left hip will be measured and serum bone metabolism parameters assessed. Polymorphisms of genes related to vitamin D metabolism and transportation will be detected, and their relationship with the risk of osteoporosis, and osteoporotic fracture, will be analysed. About 18 000 residents will be involved in the study.
The study was approved by Institutional Ethics Board of Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine (2016LCSY065). Results will be published in peer-reviewed journals. The results of this study are expected to improve the understanding of the association between polymorphisms of genes related to vitamin D metabolism and transportation and the risk of osteoporosis and osteoporotic fracture among middle-aged and older residents of China.
NCT02958020.
骨质疏松性骨折是导致残疾的最常见原因之一，也是世界许多地区医疗费用的主要组成部分。与维生素D代谢和转运相关的基因多态性与骨密度变化及骨质疏松风险有关。
中国社区骨质疏松队列研究是一项针对中国中老年常住人口的观察性、纵向、多中心、前瞻性队列研究，自2016年起在六个城市开展。通过常住人口名单确定年龄在45 - 80岁的女性居民和年龄在50 - 80岁的男性居民。所有纳入的参与者将完成关于其个人特征和病史的问卷调查。测量他们腰椎和左髋的骨密度，并评估血清骨代谢参数。检测与维生素D代谢和转运相关的基因多态性，并分析其与骨质疏松风险及骨质疏松性骨折的关系。约18000名居民将参与该研究。
本研究已获得上海中医药大学附属龙华医院机构伦理委员会批准（2016LCSY065）。研究结果将在同行评审期刊上发表。本研究结果有望增进对中国中老年居民中与维生素D代谢和转运相关的基因多态性与骨质疏松及骨质疏松性骨折风险之间关联的理解。
NCT02958020。
