血清维生素 B 浓度与中国中老年人骨质疏松症风险的关联：一项横断面研究。
Association between serum vitamin B concentration and risk of osteoporosis in the middle-aged and older people in China: a cross-sectional study.
机构信息
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Key Laboratory, Ministry of Education of China, Shanghai, China.
出版信息
BMJ Open. 2019 Jul 4;9(7):e028129. doi: 10.1136/bmjopen-2018-028129.
OBJECTIVE
To determine the relationship between serum vitamin B (Vit B) concentration and the status of bone mineral density and identify the relationship between serum Vit B6 and bone metabolism parameters in middle-aged and older people in China.
DESIGN
The present study was a cross-sectional study within the framework of an ongoing prospective population-based cohort study.
SETTING AND PARTICIPANTS
A total of 1829 residents (men ≥50 years and women ≥45 years) from two subdistricts were recruited from July 2015 to February 2016 in Shanghai, China.
MEASURES
Recruited residents were grouped (control, osteopenia and osteoporosis) according to their lumbar spine bone mineral density, measured through dual-energy X-ray absorptiometry. Serum Vit B concentrations, bone turnover marker concentrations and calcium and phosphorus metabolism parameters were assessed.
RESULTS
No significant linear trend between serum Vit B concentrations and lumbar bone mass was observed in the men. In the women, the average osteoporosis risk was 61% higher at serum Vit B concentrations of <19.2 μg/L than at those of >26.9 μg/L (OR 1.61, 95% CI 1.00 to 2.58). However, there was no significance after controlling of serum 25-hydroxy-vitamin D concentration and parathyroid hormone concentration, respectively. In the osteoporotic women, the serum Vit B concentration was significantly negatively correlated to concentrations of bone turnover marker including N-terminal propeptide of type I collagen, β-C-terminal telopeptide of type I collagen and osteocalcin. It was also positively related to the serum 25-hydroxy-vitamin D concentration and inversely related to the serum parathyroid hormone concentration.
CONCLUSIONS
A relatively low serum Vit B concentration, even in the normal range, may be a risk factor for osteoporosis in postmenopausal women, which is dependent on serum 25-hydroxy-vitamin D concentration and parathyroid hormone concentration.
TRIAL REGISTRATION NUMBER
NCT02958020; Post-results.
目的
确定血清维生素 B（Vit B）浓度与骨密度状况之间的关系，并确定中国中老年人血清 Vit B6 与骨代谢参数之间的关系。
设计
本研究是一项在正在进行的前瞻性人群队列研究框架内进行的横断面研究。
地点和参与者
2015 年 7 月至 2016 年 2 月，共招募了来自中国上海两个分区的 1829 名居民（男性≥50 岁，女性≥45 岁）。
措施
根据腰椎骨矿物质密度，通过双能 X 射线吸收法将招募的居民分为（对照组、骨量减少和骨质疏松症）组。评估血清 Vit B 浓度、骨转换标志物浓度以及钙磷代谢参数。
结果
在男性中，血清 Vit B 浓度与腰椎骨量之间没有明显的线性趋势。在女性中，血清 Vit B 浓度<19.2μg/L 时，平均骨质疏松症风险比>26.9μg/L 时高 61%（OR 1.61，95%CI 1.00 至 2.58）。然而，分别控制血清 25-羟维生素 D 浓度和甲状旁腺激素浓度后，无显著性差异。在骨质疏松症女性中，血清 Vit B 浓度与包括Ⅰ型胶原 N 端前肽、Ⅰ型胶原β C 端端肽和骨钙素在内的骨转换标志物的浓度呈显著负相关。它也与血清 25-羟维生素 D 浓度呈正相关，与血清甲状旁腺激素浓度呈负相关。
结论
即使在正常范围内，相对较低的血清 Vit B 浓度可能是绝经后妇女骨质疏松症的一个危险因素，这取决于血清 25-羟维生素 D 浓度和甲状旁腺激素浓度。
试验注册号
NCT02958020；Post-results。
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