Department of Nephrology, Central South University, Xiangya Hospital, Xiangya Road No 87, Changsha, Hunan, 41008, China.
Int Urol Nephrol. 2020 Mar;52(3):497-503. doi: 10.1007/s11255-019-02335-7. Epub 2019 Nov 25.
Ferroptosis is a form of iron-dependent, non-apoptotic regulated cell death, which is characterized by the accumulation of lipid hydroperoxides to lethal levels. Ferroptosis recently has been shown to have implications in diverse kidney diseases, such as acute kidney injury, polycystic kidney disease and renal cell carcinoma. This review summarizes current research on ferroptosis, its underlying mechanisms and its role in the progression of different kidney diseases to provide more information regarding treatment and prevention of these destructive diseases.
铁死亡是一种铁依赖性的、非细胞凋亡的程序性细胞死亡形式，其特征是脂质过氧化氢的积累达到致命水平。最近的研究表明，铁死亡在多种肾脏疾病中具有重要意义，如急性肾损伤、多囊肾病和肾细胞癌。本综述总结了铁死亡、其潜在机制及其在不同肾脏疾病进展中的作用的研究现状，为这些破坏性疾病的治疗和预防提供更多信息。
