Riikonen R, von Willebrandt E
Department of Pediatrics, University of Turku, Finland.
Acta Neurol Scand. 1988 Jul;78(1):58-64. doi: 10.1111/j.1600-0404.1988.tb03620.x.
Ten patients with childhood optic neuritis (5 with a single attack of ON and 5 with later MS) were studied at various stages of the disease. Lymphocyte count and function were analysed in the peripheral blood of all patients, 3 repeatedly, and in one they were also analysed in the CSF. T-lymphocytes counts were normal in all but 2 MS cases who had high counts. In acute stages the T4/T8 ratio were high in 1/3 determinations, in recovery low in 2/2 determinations, and in stable stages normal in 6/8 determinations. Lymphocyte function, measured by PHA, ConA and PWM stimulation, was normal in all but one. One patient showed significantly higher T-cell percentages and a high number of stimulated lymphocytes in CSF but a lower count of suppressor cells than in the blood. We found no abnormalities specific to MS nor to childhood MS or to disease activity stage. Rather than peripheral blood, it would seem more worthwhile to study CSF to clarify the pathogenesis of ON and MS.
对10例儿童视神经炎患者（5例为单次视神经炎发作，5例随后发展为多发性硬化症）在疾病的不同阶段进行了研究。分析了所有患者外周血中的淋巴细胞计数和功能，其中3例进行了重复分析，1例还对脑脊液进行了分析。除2例多发性硬化症患者淋巴细胞计数较高外，其余患者的T淋巴细胞计数均正常。在急性期，三分之一的检测中T4/T8比值较高，恢复期二分之二的检测中该比值较低，稳定期八分之六的检测中该比值正常。通过PHA、ConA和PWM刺激检测的淋巴细胞功能，除1例患者外均正常。1例患者脑脊液中的T细胞百分比显著更高，刺激淋巴细胞数量较多，但抑制细胞计数低于血液中的计数。我们未发现多发性硬化症、儿童多发性硬化症或疾病活动阶段特有的异常情况。为阐明视神经炎和多发性硬化症的发病机制，研究脑脊液似乎比研究外周血更有价值。
