Bistoletti P, Hjerpe A, Möllerström G
Department of Obstetrics and Gynecology, Huddinge University Hospital, Karolinska Institutet, Sweden.
Acta Obstet Gynecol Scand. 1988;67(4):343-5.
The value of the Endo-Pap endometrial cell sampling device in the cytological assessment of the endometrium was compared with fractional curettage. 318 symptomatic women were studied consecutively, among whom were 42 with malignant tumors of the uterus. Satisfactory material for cytological diagnosis of the endometrial state was obtained in 96%, whereas only 91% of the histopathological material was suitable for interpretation. 35 of 36 women with primary cancers of the corpus uteri had atypical endometrial cytology (sensitivity 0.97). Of 42 uterine cancers, including one metastatic ovarian carcinoma, two adenocarcinomas and three squamous carcinomas of the cervix, 40 were detected by endometrial cytology (sensitivity 0.95). All 5 cases of high grade cytological atypia in endometrial polyps or endometrial hyperplasia could be diagnosed by abnormal endometrial cytology and 4 of 5 patients with adenomatous endometrial hyperplasia were diagnosed correctly. Endometrial cytology obtained with the Endo-Pap sampler is a simple and cheap diagnostic method with which to detect endometrial cancer. It is also effective for diagnosis of preinvasive endometrial lesions with highgrade cytological atypia. Clinicians should recognize that out-patient investigation of the endometrial state by endometrial cell sampling with the Endo-Pap is reliable and can usually replace fractional curettage.
将Endo-Pap子宫内膜细胞采样装置在子宫内膜细胞学评估中的价值与分段刮宫术进行了比较。对318名有症状的女性进行了连续研究，其中42人患有子宫恶性肿瘤。96%的患者获得了用于子宫内膜状态细胞学诊断的满意材料，而只有91%的组织病理学材料适合解读。36例子宫体原发性癌患者中有35例子宫内膜细胞学表现不典型（敏感性0.97）。在42例子宫癌中，包括1例转移性卵巢癌、2例腺癌和3例宫颈鳞癌，40例通过子宫内膜细胞学检查被检测出来（敏感性0.95）。子宫内膜息肉或子宫内膜增生中所有5例高级别细胞学不典型病例均可通过异常子宫内膜细胞学诊断，5例腺瘤性子宫内膜增生患者中有4例被正确诊断。使用Endo-Pap采样器获得的子宫内膜细胞学检查是一种简单且廉价的诊断方法，可用于检测子宫内膜癌。它对于诊断具有高级别细胞学不典型的子宫内膜癌前病变也有效。临床医生应认识到，使用Endo-Pap进行子宫内膜细胞采样对子宫内膜状态进行门诊检查是可靠的，通常可以替代分段刮宫术。
