M. Teng, Y.J. Zhao, A.L. Khoo, and B.P. Lim are with the Pharmacy and Therapeutics Office, Group Health Informatics, National Healthcare Group, Singapore.
T.C. Yeo is with the Department of Cardiology, National University Heart Centre, Singapore.
Nutr Rev. 2020 Mar 1;78(3):249-259. doi: 10.1093/nutrit/nuz074.
Coconut oil is rich in medium-chain fatty acids and has been claimed to have numerous health benefits.
This review aimed to examine the evidence surrounding coconut oil consumption and its impact on cardiovascular health.
A systematic literature search of the PubMed, Embase, the Cochrane Library, and CINAHL databases, up to May 2019, was performed.
Study characteristics including study design, population, intervention, comparator, outcome, and source of funding were summarized.
Meta-analyses included 12 studies to provide estimates of effects. Subgroup analyses were performed to account for any differences in the study-level characteristics. When compared with plant oils and animal oils, coconut oil was found to significantly increase high-density lipoprotein cholesterol (HDL-C) by 0.57 mg/dL (95%CI, 0.40-0.74 mg/dL; I2 = 6.7%) and 0.33 mg/dL (0.01-0.65 mg/dL; I2 = 0%), respectively. Coconut oil significantly raised low-density lipoprotein cholesterol (LDL-C) by 0.26 mg/dL (0.09-0.43 mg/dL; I2 = 59.7%) compared with plant oils and lowered LDL-C (-0.37 mg/dL; -0.69 to -0.05 mg/dL; I2 = 48.1%) compared with animal oils. No significant effects on triglyceride were observed. Better lipid profiles were demonstrated with the virgin form of coconut oil.
Compared with animal oils, coconut oil demonstrated a better lipid profile n comparison with plant oils, coconut oil significantly increased HDL-C and LDL-C.
椰子油富含中链脂肪酸，据称具有许多健康益处。
本综述旨在研究椰子油消费及其对心血管健康影响的证据。
对 PubMed、Embase、Cochrane 图书馆和 CINAHL 数据库进行了系统的文献检索，截至 2019 年 5 月。
总结了研究特征，包括研究设计、人群、干预、对照、结局和资金来源。
荟萃分析纳入了 12 项研究，以提供对效果的估计。进行了亚组分析，以说明研究水平特征的任何差异。与植物油和动物油相比，发现椰子油可分别显著增加高密度脂蛋白胆固醇（HDL-C）0.57mg/dL（95%CI，0.40-0.74mg/dL；I2=6.7%）和 0.33mg/dL（0.01-0.65mg/dL；I2=0%）。与植物油相比，椰子油可使低密度脂蛋白胆固醇（LDL-C）显著升高 0.26mg/dL（0.09-0.43mg/dL；I2=59.7%），与动物油相比，可使 LDL-C 降低 0.37mg/dL（-0.69 至-0.05mg/dL；I2=48.1%）。甘油三酯无显著影响。与椰子油相比，椰子油的原始形式表现出更好的血脂谱。
与动物油相比，椰子油对血脂谱的改善优于植物油，与植物油相比，椰子油可显著增加 HDL-C 和 LDL-C。
