School of Ophthalmology & Optometry, Eye Hospital, School of Biomedical Engineering , Wenzhou Medical University , Wenzhou , Zhejiang 325027 , China.
Wenzhou Institute of Biomaterials and Engineering, Wenzhou Institute , University of Chinese Academy of Sciences , Wenzhou , Zhejiang 325011 , China.
ACS Appl Mater Interfaces. 2019 Dec 18;11(50):46558-46571. doi: 10.1021/acsami.9b17543. Epub 2019 Dec 5.
Rapid water absorption rate has become a bottleneck that limits ultrarapid hemostatic performance of hemostatic microspheres. Herein, we reported a "lotus seedpod surface-like" polysaccharide hemostatic microsphere (PHM) with "macropits on surface" morphology and "micropores in macropits" structure. Unique macropits on surface can promote the water absorption rate because they are advantageous to quickly guide blood into the micropores. Special micropores are internally connected with each other, which endows PHM with high water absorption ratio. During the process of blood entering the micropores from micropits, the pore size decreases gradually. In this way, blood clotting factors could be rapidly concentrated. PHM showed the highest water absorption rate (40.7 mL/s/cm) and rapid hemostatic property in vivo (hemostatic time shortened from 210 to 45 s). Lotus seedpod surface-like PHMs are believed to have further clinical application as an effective hemostasis.
快速吸水速率已成为限制止血微球超快止血性能的瓶颈。在此，我们报道了一种具有“表面似莲蓬”形貌和“大孔中有微孔”结构的多糖止血微球（PHM）。表面独特的大孔有利于快速引导血液进入微孔，从而促进吸水速率。特殊的微孔内部相互连通，使 PHM 具有高吸水率。当血液从小孔进入微孔时，孔径逐渐减小。这样，凝血因子可以迅速浓缩。PHM 表现出最高的吸水速率（40.7 mL/s/cm）和体内快速止血性能（止血时间从 210 秒缩短至 45 秒）。具有表面似莲蓬的 PHM 有望作为一种有效的止血剂进一步临床应用。
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