循环脂肪细胞因子内脏脂肪素、Apelin和内脂素在体重不足儿童食欲不振中的作用：一项试点试验。
Role of circulating adipocytokines vaspin, apelin, and visfatin in the loss of appetite in underweight children: a pilot trial.
作者信息
Vehapoglu Aysel, Ustabas Feyza, Ozgen Tolga I, Terzioglu Sule, Cermik Banu B, Ozen Omer F
出版信息
J Pediatr Endocrinol Metab. 2015 Sep;28(9-10):1065-71. doi: 10.1515/jpem-2014-0490.
OBJECTIVES
To investigate serum concentrations of vaspin, apelin, and visfatin in underweight children and their association with anthropometric and nutritional markers of malnutrition.
SUBJECTS AND METHODS
We recruited 44 underweight prepubertal children (youngest age = 2 years) with thinness grades of 1, 2, and 3, and body weights < 90% of ideal body weight due to loss of appetite and less frequent hunger episodes. Forty-one healthy age- and gender-matched controls were also included in the study. Serum fasting vaspin, apelin, and visfatin concentrations were measured by enzyme immunoassay technique.
RESULTS
Mean vaspin and apelin levels were significantly lower in underweight children compared to controls (vaspin: 0.44 ± 0.18 vs. 0.58 ± 0.35 pg/mL, p = 0.024; apelin: 483.37 ± 333.26 vs. 711.71 ± 616.50 pg/mL, p = 0.041). Visfatin levels were lower in underweight children compared to controls, but the values were not statistically significant (177.81 ± 158.01 vs. 221.15 ± 212.94 pg/mL, p = 0.119).
CONCLUSIONS
In underweight children, decreased vaspin and apelin levels should be considered in the etiology of anorexia.
目的
研究体重不足儿童血清内脂素、apelin和内脏脂肪素的浓度及其与营养不良的人体测量和营养指标之间的关联。
对象与方法
我们招募了44名青春期前体重不足的儿童（最小年龄为2岁），消瘦程度为1、2和3级，因食欲不振和饥饿发作频率较低，体重<理想体重的90%。41名年龄和性别匹配的健康对照者也纳入了该研究。采用酶免疫测定技术测量血清空腹内脂素、apelin和内脏脂肪素浓度。
结果
与对照组相比，体重不足儿童的平均内脂素和apelin水平显著降低（内脂素：0.44±0.18 vs. 0.58±0.35 pg/mL，p = 0.024；apelin：483.37±333.26 vs. 711.71±616.50 pg/mL，p = 0.041）。与对照组相比，体重不足儿童的内脏脂肪素水平较低，但差异无统计学意义（177.81±158.01 vs. 221.15±212.94 pg/mL，p = 0.119）。
结论
在体重不足儿童中，内脂素和apelin水平降低应被视为厌食症病因的考虑因素。
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