Reid J D, Andersen M E
Pathology Department, Robinson Memorial Hospital, Ravenna, Ohio.
Am J Clin Pathol. 1988 Nov;90(5):545-58. doi: 10.1093/ajcp/90.5.545.
The nature, prevalence, and specificity of birefringent calcific particles in granulomas of sarcoidosis have been examined, including histochemical reactions, single particle, and microchemical analyses. Particular attention was paid to small ovoid forms of which most were calcium oxalate monohydrate. Larger crystals, those within giant cells, and the birefringent component of a Schaumann complex were also calcium oxalate. Small ovoids appeared to originate in macrophages and to be precursors of other forms; they were found in 86% of lymph nodes and 73% of surgical lung specimens. They were not specific for sarcoidosis. Organisms could not be certainly identified in them. Their origin is discussed in relation to activated macrophages, calcium, and oxalate metabolism, and the role of calcium oxalate in granulomas is considered. Four particles from two cases were dolomite and two were a calcium-sulphur compound. The biologic origin of dolomite is reviewed.
对结节病肉芽肿中双折射钙化颗粒的性质、患病率和特异性进行了研究，包括组织化学反应、单颗粒和微量化学分析。特别关注了小卵形颗粒，其中大多数是一水合草酸钙。较大的晶体、巨细胞内的晶体以及绍曼复合体的双折射成分也是草酸钙。小卵形颗粒似乎起源于巨噬细胞，是其他形式的前体；在86%的淋巴结和73%的手术肺标本中发现了它们。它们并非结节病所特有。在其中无法确切鉴定出生物体。结合活化巨噬细胞、钙和草酸盐代谢讨论了它们的起源，并考虑了草酸钙在肉芽肿中的作用。两例中的四个颗粒是白云石，两个是钙硫化合物。对白云石的生物学起源进行了综述。
