Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, Messina, Italy.
Department of Biomedical Sciences, Dental and of Morphological and Functional Images, University of Messina, Messina, Italy.
Free Radic Res. 2020 Jan;54(1):57-63. doi: 10.1080/10715762.2019.1698738. Epub 2019 Dec 10.
Glutathione S-transferases (GST) are antioxidant enzymes with frequent genetic polymorphisms. Homozygosis for gene deletion ("null" genotype) of and , causing decrease of the antioxidant potential of the organism, is frequent, with variable frequency in different ethnic contexts. Although oxidative stress notoriously plays a role in the pathogenesis of psoriasis, few studies exist on the association between / genotype and psoriasis, with different results. We aimed to assess the frequency of / polymorphisms in Southern Italian psoriatic patients and controls and investigate the association of the / genotype with individual and disease parameters. To this aim, the / genotype of 148 psoriatic patients and 148 age- and sex-matched controls was defined by PCR on oral mucosa cells. null was associated with psoriasis (55.4% of patients vs. 25% of controls, = 9.58 × 10, odds ratio 3.73), while null was not. The / "double null" genotype conferred an even higher odds ratio for psoriasis (5.94). The association between psoriasis and null was stronger in women (54.1% of patients vs. 19.7% of controls, = 8.13 × 10) than in men (56.3% of patients vs. 28.7% of controls, = 0.0002). No association was found between / genotype and psoriasis severity, age of onset or comorbidities (psoriatic arthritis, metabolic syndrome). The remarkable differences among the few available data on the association between / polymorphisms and psoriasis suggest the need for further studies, on different and larger populations, to improve knowledge on the pathogenesis of psoriasis and possibly provide more precise and personalised prevention and treatment in the future.
谷胱甘肽 S-转移酶（GST）是具有频繁遗传多态性的抗氧化酶。和基因缺失的纯合子（“null”基因型），导致机体抗氧化能力下降，在不同的种族背景中较为常见，但其频率存在差异。虽然氧化应激在银屑病的发病机制中起着明显的作用，但关于 / 基因型与银屑病之间的关联的研究较少，且结果存在差异。我们旨在评估南意大利银屑病患者和对照组中 / 多态性的频率，并研究 / 基因型与个体和疾病参数的关联。为此，通过口腔黏膜细胞的 PCR 方法确定了 148 例银屑病患者和 148 名年龄和性别匹配的对照组的 / 基因型。null 与银屑病相关（55.4%的患者 vs. 25%的对照组， = 9.58 × 10，优势比 3.73），而 null 则不然。/“双 null”基因型使银屑病的优势比更高（5.94）。在女性中，银屑病与 null 的关联更强（54.1%的患者 vs. 19.7%的对照组， = 8.13 × 10），而在男性中则较弱（56.3%的患者 vs. 28.7%的对照组， = 0.0002）。在银屑病严重程度、发病年龄或合并症（银屑病关节炎、代谢综合征）方面，未发现 / 基因型与银屑病之间存在关联。在少数关于 / 多态性与银屑病之间关联的现有数据中存在显著差异，这表明需要进一步研究不同人群和更大人群中的情况，以增进对银屑病发病机制的了解，并可能在未来提供更精确和个性化的预防和治疗。
