School of Pharmacy and Food Sciences, Zhuhai College of Jilin University, Zhuhai 519041, China.
School of Environment and Energy, South China University of Technology, Guangzhou 510006, China.
Molecules. 2019 Nov 25;24(23):4286. doi: 10.3390/molecules24234286.
Seaweeds are some of the largest producers of biomass in the marine environment and are rich in bioactive compounds that are often used for human and animal health. Porphyran and carrageenan are natural compounds derived from red seaweeds. The former is a characteristic polysaccharide of , while the latter is well known from , , and various species, all in Rhodophyceae. The two polysaccharides have been found to have anti-cancer activity by improving immunity and targeting key apoptotic molecules and therefore deemed as potential chemotherapeutic or chemopreventive agents. This review attempts to review the current study of anti-cancer activity and the possible mechanisms of porphyran and carrageenan derived from red seaweeds to various cancers, and their cooperative actions with other anti-cancer chemotherapeutic agents is also discussed.
海藻是海洋环境中最大的生物量生产者之一，富含生物活性化合物，常用于人类和动物健康。褐藻胶和卡拉胶是从红海藻中提取的天然化合物。前者是 的特征多糖，而后者则来自 、 和各种 物种，均属于红藻门。这两种多糖已被发现通过改善免疫和靶向关键凋亡分子具有抗癌活性，因此被认为是有潜力的化疗或化学预防药物。本综述试图综述来自红海藻的褐藻胶和卡拉胶的抗癌活性及其可能机制的最新研究，并讨论它们与其他抗癌化疗药物的协同作用。
