性类固醇对生长中兔子峰值骨密度的影响。

Effect of sex steroids on peak bone density of growing rabbits.

作者信息

Gilsanz V, Roe T F, Gibbens D T, Schulz E E, Carlson M E, Gonzalez O, Boechat M I

机构信息

Department of Radiology, University of Southern California, School of Medicine, Childrens Hospital of Los Angeles 90054-0700.

出版信息

Am J Physiol. 1988 Oct;255(4 Pt 1):E416-21. doi: 10.1152/ajpendo.1988.255.4.E416.

DOI:10.1152/ajpendo.1988.255.4.E416

PMID:3177632

Abstract

To determine the effect of sex hormones on bone density (BD) during growth, longitudinal quantitative computed tomography (QCT) measurements were obtained in growing, castrated New Zealand White rabbits following administration of normal saline, testosterone, or estrogen from 6 wk of age until the time of skeletal maturity. Vertebral QCT densities increased during growth, were highest at the time of epiphyseal closure, and were significantly greater (P less than 0.001) in hormone-treated animals. In vivo QCT measurements in 12 vertebraes correlated strongly (r = 0.92) with percentage of calcium per weight assessed in vitro by neutron activation analysis.

摘要

为了确定生长期间性激素对骨密度（BD）的影响，对6周龄至骨骼成熟时接受生理盐水、睾酮或雌激素处理的生长中去势新西兰白兔进行了纵向定量计算机断层扫描（QCT）测量。椎体QCT密度在生长过程中增加，在骨骺闭合时最高，且激素处理组动物的椎体QCT密度显著更高（P<0.001）。12个椎体的体内QCT测量值与通过中子活化分析体外评估的每重量钙百分比密切相关（r=0.92）。