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脑钠肽和利钠肽受体 A（NPR-A）在慢性非细菌性前列腺炎大鼠 L6-S1 背根神经节中的表达和调节。

Expression and Regulation of Brain Natriuretic Peptide and Natriuretic Peptide Receptor A (NPR-A) in L6-S1 Dorsal Root Ganglia in a Rat Model of Chronic Nonbacterial Prostatitis.

机构信息

Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).

Department of Urology, The Peoples' Hospital of Ganzhou City, Ganzhou, Jiangxi, China (mainland).

出版信息

Med Sci Monit. 2019 Nov 28;25:9042-9047. doi: 10.12659/MSM.915619.

DOI:10.12659/MSM.915619
PMID:31777403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6900924/
Abstract

BACKGROUND The study aimed to investigate the expression of brain natriuretic peptide (BNP) and natriuretic peptide receptor A (NPR-A) in L6-S1 dorsal root ganglia (DRG) in a rat model of chronic nonbacterial prostatitis (CNP). MATERIAL AND METHODS One hundred specific pathogen-free (SPF) male Sprague-Dawley rats were randomly divided into a control group (N=50) and a study group (N=50). The control group underwent prostatic injection of 0.1 ml of normal saline on days 3, 7, 10, 14, and 28. The study group, or rat model of CNP, underwent prostatic injection of 0.1 ml of complete Freund's adjuvant on days 3, 7, 10, 14, and 28. At the end of the study, the rats were euthanized, and the prostate tissues and L6-S1 DRG were removed. Histology was performed on the prostate tissue from the rats in the study group and control group. Real-time fluorescence-based quantitative polymerase chain reaction (PCR) and Western blot were used to study the expression of BNP and NPR-A mRNA and protein in the DRG from the rats in the study group and control group. RESULTS In the rat model of CNP, the expression of BNP and NPR-A were significantly increased in L6-S1 DRG compared with the controls. CONCLUSIONS In a rat model of CNP, the increased expression of BNP and NPR-A in L6-S1 DRG may have a role in pain signaling pathways associated with chronic prostatitis.

摘要

背景

本研究旨在探讨脑钠肽（BNP）和利钠肽受体 A（NPR-A）在慢性非细菌性前列腺炎（CNP）大鼠模型 L6-S1 背根神经节（DRG）中的表达。

材料与方法

100 只 SPF 雄性 Sprague-Dawley 大鼠随机分为对照组（N=50）和研究组（N=50）。对照组在第 3、7、10、14 和 28 天分别向前列腺注射 0.1ml 生理盐水。研究组，即 CNP 大鼠模型，在第 3、7、10、14 和 28 天分别向前列腺注射 0.1ml 完全弗氏佐剂。研究结束时，处死大鼠，取出前列腺组织和 L6-S1DRG。对研究组和对照组大鼠的前列腺组织进行组织学检查。采用实时荧光定量聚合酶链反应（PCR）和 Western blot 研究研究组和对照组大鼠 DRG 中 BNP 和 NPR-A mRNA 和蛋白的表达。

结果

在 CNP 大鼠模型中，与对照组相比，L6-S1 DRG 中 BNP 和 NPR-A 的表达明显增加。

结论

在 CNP 大鼠模型中，L6-S1 DRG 中 BNP 和 NPR-A 的表达增加可能与慢性前列腺炎相关的疼痛信号通路有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eea3/6900924/324c0da19614/medscimonit-25-9042-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eea3/6900924/1a8e55c2a9f4/medscimonit-25-9042-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eea3/6900924/c6bc072b832e/medscimonit-25-9042-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eea3/6900924/324c0da19614/medscimonit-25-9042-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eea3/6900924/1a8e55c2a9f4/medscimonit-25-9042-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eea3/6900924/c6bc072b832e/medscimonit-25-9042-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eea3/6900924/324c0da19614/medscimonit-25-9042-g003.jpg

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Effect of Tripterygium Wilfordii Polyglycoside on Experimental Prostatitis Caused by Ureaplasma Urealyticum in Rats.
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Med Sci Monit. 2016 Oct 15;22:3722-3726. doi: 10.12659/msm.897360.
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Testosterone-induced relaxation of coronary arteries: activation of BKCa channels via the cGMP-dependent protein kinase.睾酮诱导冠状动脉舒张：通过 cGMP 依赖蛋白激酶激活 BKCa 通道。
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