Bai Huiming, Cao Hongwen, Wang Dan, Chen Lei, Feng Yigeng, Gao Renjie
Department of Urology, Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai, China.
Am J Transl Res. 2021 Aug 15;13(8):9241-9247. eCollection 2021.
To investigate the feasibility and effectiveness of Xialiqi capsules in rats with nonbacterial prostatitis.
A total of 90 healthy male SD rats, weighing 200-220 g, were randomly divided into a blank control group (BCG, n=30), a model group (MG, n=30), and an intervention group (IG, n=30). After establishing the model of chronic nonbacterial prostatitis, IG was treated with 50 mg/kg Xialiqi capsules via gavage. The three groups received the same dose of saline via gavage for 7 consecutive days. The differences in leukocytes, phospholipid vesicle density, number of colonies, prostate mass, apparent diffusion coefficient (ADC), degree of inflammatory cell infiltration in the prostate fluid, serum tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-8, CD3+, CD8+ levels after intervention were compared in the three groups.
Compared with the BCG, the number of leukocytes and colonies in the prostate fluid of the MG was elevated, and the density of lipid vesicles was decreased, and the number of leukocytes and colonies in the prostate fluid of the MG significantly decreased and the density of lipid vesicles rebounded after the intervention of Xialiqi capsules (>0.05). Compared with the BCG, the prostate mass, ADC and the degree of inflammatory cell infiltration were elevated in the MG. There was a significant reversion of the above indices after the intervention of Xialiqi capsules (<0.05). The serum levels of TNF-α, IL-6 and IL-8 in the MG were significantly higher than those in the IG, and the levels in the IG were higher than that in the BCG (<0.05). The serum levels of CD3+ and CD8+ in the MG were significantly lower than those in the IG, and the levels in the IG were lower than that in the BCG (<0.05).
Xialiqi capsules have a good intervention effect on nonbacterial prostatitis, which can significantly alleviate the immune status and reduce the level of cytokines in the serum and tissues of rats.
探讨夏荔芪胶囊对非细菌性前列腺炎大鼠的可行性及有效性。
选取90只体重200 - 220 g的健康雄性SD大鼠，随机分为空白对照组（BCG，n = 30）、模型组（MG，n = 30）和干预组（IG，n = 30）。建立慢性非细菌性前列腺炎模型后，干预组给予50 mg/kg夏荔芪胶囊灌胃，连续7天，三组均给予相同剂量生理盐水灌胃。比较三组干预后前列腺液中白细胞、磷脂小体密度、菌落数、前列腺质量、表观扩散系数（ADC）、炎症细胞浸润程度，血清肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-6、IL-8、CD3 +、CD8 +水平的差异。
与空白对照组相比，模型组前列腺液中白细胞及菌落数升高，脂质小体密度降低，夏荔芪胶囊干预后模型组前列腺液中白细胞及菌落数显著降低，脂质小体密度回升（P > 0.05）。与空白对照组相比，模型组前列腺质量、ADC及炎症细胞浸润程度升高，夏荔芪胶囊干预后上述指标有显著逆转（P < 0.05）。模型组血清TNF-α、IL-6及IL-8水平显著高于干预组，干预组高于空白对照组（P < 0.05）。模型组血清CD3 +、CD8 +水平显著低于干预组，干预组低于空白对照组（P < 0.05）。
夏荔芪胶囊对非细菌性前列腺炎有良好的干预作用，可显著改善大鼠免疫状态，降低血清及组织中细胞因子水平。
