Wei Linyu, Mousawi Fatema, Li Dongliang, Roger Sébastien, Li Jing, Yang Xuebin, Jiang Lin-Hua
Sino-UK Joint Laboratory of Brain Function and Injury and Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, China.
School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Front Pharmacol. 2019 Nov 6;10:1304. doi: 10.3389/fphar.2019.01304. eCollection 2019.
Organs and tissues and their constituent cells are physiologically submitted to diverse types of mechanical forces or stress, one common sequence of which is release of intracellular ATP into extracellular space. Extracellular ATP is a well-established autocrine or paracrine signaling molecule that regulates multiple cell functions and mediates cell-to-cell communications activating the purinergic P2 receptors, more specifically, ligand-gated ion channel P2X receptors and some of the G-protein-coupled P2Y receptors. The molecular mechanisms that sense mechanical and transduce forces to trigger ATP release are poorly understood. The Piezo1, a newly identified mechanosensing ion channel, shows widespread expression and confers mechanosensitivity in many different types of cells. In this mini-review, we briefly introduce the Piezo1 channel and discuss the evidence that supports its important role in the mechanoregulation of diverse cell functions and, more specifically, critical engagement of ATP release and subsequent P2 receptor activation in Piezo1 channel-dependent mechanoregulation. Such ATP release-mediated coupling of the Piezo1 channel and P2 receptors may serve a signaling mechanism that is more common than we currently understand in transducing mechanical information to regulation of the attendant cell functions in various organs and tissues.
器官、组织及其组成细胞在生理上会受到多种类型的机械力或应力作用，其中一个常见的过程是细胞内ATP释放到细胞外空间。细胞外ATP是一种公认的自分泌或旁分泌信号分子，它调节多种细胞功能并介导细胞间通讯，激活嘌呤能P2受体，更具体地说，是配体门控离子通道P2X受体和一些G蛋白偶联P2Y受体。目前对感知机械力并将其转化为触发ATP释放的分子机制了解甚少。Piezo1是一种新发现的机械敏感离子通道，在许多不同类型的细胞中广泛表达并赋予细胞机械敏感性。在这篇小型综述中，我们简要介绍Piezo1通道，并讨论支持其在多种细胞功能的机械调节中发挥重要作用的证据，更具体地说，是在Piezo1通道依赖性机械调节中ATP释放及随后P2受体激活的关键作用。这种由ATP释放介导的Piezo1通道与P2受体的偶联可能是一种信号机制，在将机械信息转化为各种器官和组织中伴随的细胞功能调节方面，其普遍性可能超出我们目前的认知。
