Mark J, Havel G, Grepp C, Dahlenfors R, Wedell B
Department of Cytogenetics, Central Hospital, Skövde, Sweden.
Anticancer Res. 1988 Jul-Aug;8(4):621-6.
Detailed observations by banding technique in 21 cultured human benign uterine leiomyomas are reported. More than half of the tumors (51%) had a primary or secondary abnormal stemline. The abnormal stemlines were usually characterized only by structural changes, in particular reciprocal translocations. These translocations, as well as instances of inversions, predominantly affected the chromosome types Nos. 1,2 and 12 and preferentially the regions 1p36, 2p24 and 12q14-15. Available data concerning cytogenetical deviations in benign human tumor types indicate that, in contrast to most malignant neoplasms, they are characterized by comparatively few and simple, either numerical or, more frequently, structural changes. The biological implications of these deviations are rapidly emerging as one of the most urgent areas for future studies with molecular techniques.
本文报告了对21例培养的人类良性子宫平滑肌瘤采用染色体显带技术进行的详细观察结果。超过半数的肿瘤（51%）具有原发性或继发性异常干系。异常干系通常仅表现为结构改变，尤其是相互易位。这些易位以及倒位情况主要影响1号、2号和12号染色体类型，且优先影响1p36、2p24和12q14 - 15区域。关于人类良性肿瘤类型细胞遗传学偏差的现有数据表明，与大多数恶性肿瘤相反，它们的特征是相对较少且简单的数值或更常见的结构改变。随着分子技术的发展，这些偏差的生物学意义正迅速成为未来研究中最紧迫的领域之一。
