乙型肝炎病毒 X 蛋白诱导 ROR 表达促进肝癌细胞的迁移和增殖。
Hepatitis B Virus X Protein-Induced ROR Expression to Promote the Migration and Proliferation of Hepatocellular Carcinoma.
机构信息
Department of Hepatobiliary Surgery, The Guangxi Zhuang Autonomous Region People's Hospital, Nanning 530021, China.
Beihai Institute of Endocrine and Metabolic Diseases, Ninth Affiliated Hospital of Guangxi Medical University, Beihai 536000, China.
出版信息
Biomed Res Int. 2019 Nov 3;2019:5407126. doi: 10.1155/2019/5407126. eCollection 2019.
Aberrant expression of ROR is implicated in cancer development. A previous study identified that ROR functions as a tumor promoter to drive hepatocellular carcinoma (HCC) growth. However, its expression and significance in HCC remain unclear. The central finding of this work is that ROR was overexpressed in HCC due to its dysfunction of promoter methylation, and hepatitis B virus X protein (HBx) can remarkably induce the expression of ROR in hepatocellular carcinoma through enhancing the transcriptional function. Also, the HBx-induced ROR could promote the migration and proliferation of hepatoma cells. Hence, these results suggest that ROR was an important regulator in HCC, and our finding provides new insights into the significance of ROR in HCC.
ROR 的异常表达与癌症的发生发展有关。之前的研究表明，ROR 作为一种肿瘤促进因子，可促进肝细胞癌（HCC）的生长。然而，其在 HCC 中的表达和意义尚不清楚。本研究的主要发现是，由于启动子甲基化功能障碍，ROR 在 HCC 中过度表达，乙型肝炎病毒 X 蛋白（HBx）可通过增强转录功能显著诱导 HCC 中 ROR 的表达。此外，HBx 诱导的 ROR 可促进肝癌细胞的迁移和增殖。因此，这些结果表明 ROR 是 HCC 的一个重要调控因子，我们的发现为 ROR 在 HCC 中的意义提供了新的见解。
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