Graduate School of Medicine, Yamaguchi University, Ube, 755-8505, Japan.
Department of Food Science and Technology, Faculty of Agricultural Technology, Brawijaya University, Malang, 65145, Indonesia.
Appl Microbiol Biotechnol. 2020 Jan;104(2):475-488. doi: 10.1007/s00253-019-10224-3. Epub 2019 Nov 28.
Among the so-called non-conventional yeasts, Kluyveromyces marxianus has extremely potent traits that are suitable for industrial applications. Indeed, it has been used for the production of various enzymes, chemicals, and macromolecules in addition to utilization of cell biomass as nutritional materials, feed and probiotics. The yeast is expected to be an efficient ethanol producer with advantages over Saccharomyces cerevisiae in terms of high growth rate, thermotolerance and a wide sugar assimilation spectrum. Results of comprehensive analyses of its genome and transcriptome may accelerate studies for applications of the yeast and may further increase its potential by combination with recent biotechnological tools including the CRISPR/Cas9 system. We thus review published studies by merging with information obtained from comprehensive data including genomic and transcriptomic data, which would be useful for future applications of K. marxianus.
在所谓的非常规酵母中，马克斯克鲁维酵母具有极其强大的特性，非常适合工业应用。事实上，它已经被用于生产各种酶、化学品和大分子，此外还利用细胞生物质作为营养物质、饲料和益生菌。与酿酒酵母相比，该酵母作为高效乙醇生产者具有生长速度快、耐热性和广泛的糖同化谱等优势。对其基因组和转录组的综合分析结果可能会加速对酵母的应用研究，并通过与包括 CRISPR/Cas9 系统在内的最新生物技术工具相结合，进一步提高其潜力。因此，我们通过合并包括基因组和转录组数据在内的综合数据中获得的信息，对已发表的研究进行了综述，这将有助于未来对马克斯克鲁维酵母的应用。
