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急性 A 型主动脉夹层的主动脉根部外科治疗及转归。

Surgical Management and Outcomes of the Aortic Root in Acute Type A Aortic Dissection.

机构信息

Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

Section of Vascular Surgery, Department of Surgery, Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.

出版信息

Ann Thorac Surg. 2020 Jul;110(1):136-143. doi: 10.1016/j.athoracsur.2019.10.014. Epub 2019 Nov 26.

Abstract

BACKGROUND

This study evaluated the short- and middle-term outcomes of different aortic root managements in the setting of acute type A aortic dissection (ATAAD): aortic root repair (ARR group), untouched aortic root (UAR group), and Bentall procedure (Bentall group).

METHODS

The study enrolled 673 patients (512 men; age 48.8 ± 11.2 years) between 2010 and 2015. Survival, aortic growth, reintervention, and valve function were compared between the 3 groups.

RESULTS

The ages were 50.6 ± 9.9, 49.8 ± 12.2, and 44.0 ± 12.0 years for ARR, UAR, and Bentall groups, respectively (P < .01). The mean follow-up time was 3.0 years (range, 0.5-6.8 years). The aortic root diameters in the groups were 39.0 ± 5.1 mm in ARR, 38.2 ± 4.4 mm in UAR, and 50.3 ± 6.2 mm in Bentall (P < .01). The overall 30-day mortality was 11.7% (79 of 673). There was no difference in 30-day mortality between the 3 groups (P = .58). The estimated aortic root growth rate was 0.60 ± 0.17 mm/y for ARR and 0.50 ± 0.14 mm/y for UAR. During follow-up, 28 patients (4.1%) died. Differences in 5-year survival between the 3 groups did not reach statistical significance (P = .82). Aortic insufficiency greater than grade 2+ developed in 15 patients (2.2%). There was no significant difference between ARR and UAR in freedom from aortic insufficiency greater than grade 2+ (P = .56). None of the patients experienced new dissection or underwent proximal reoperation during the follow-up period.

CONCLUSIONS

Conservative techniques (ARR and UAR) and aggressive root replacement can both be performed with excellent short- and middle-term outcomes in ATAAD. Thus, an individualized approach in managing the aortic root for ATAAD is recommended based on the patient's general condition, root pathology, and the surgeon's preference.

摘要

背景

本研究评估了急性 A 型主动脉夹层(ATAAD)患者中不同主动脉根部处理方法的短期和中期结果:主动脉根部修复(ARR 组)、未处理的主动脉根部(UAR 组)和 Bentall 手术(Bentall 组)。

方法

本研究纳入了 2010 年至 2015 年间的 673 例患者(512 例男性;年龄 48.8 ± 11.2 岁)。比较三组之间的生存、主动脉生长、再次介入和瓣膜功能。

结果

ARR、UAR 和 Bentall 组的年龄分别为 50.6 ± 9.9、49.8 ± 12.2 和 44.0 ± 12.0 岁(P<.01)。平均随访时间为 3.0 年(0.5-6.8 年)。ARR、UAR 和 Bentall 组的主动脉根部直径分别为 39.0 ± 5.1、38.2 ± 4.4 和 50.3 ± 6.2(P<.01)。总的 30 天死亡率为 11.7%(673 例中的 79 例)。三组之间 30 天死亡率无差异(P=.58)。估计的主动脉根部生长速度为 ARR 组 0.60 ± 0.17mm/y,UAR 组 0.50 ± 0.14mm/y。随访期间,28 例患者(4.1%)死亡。三组之间 5 年生存率无显著差异(P=.82)。15 例(2.2%)患者发生 2 级以上主动脉瓣关闭不全。ARR 和 UAR 之间 2 级以上主动脉瓣关闭不全无显著差异(P=.56)。随访期间无患者发生新发夹层或近端再手术。

结论

在 ATAAD 中,保守技术(ARR 和 UAR)和积极的根部置换均可获得极好的短期和中期结果。因此,建议根据患者的一般情况、根部病变和外科医生的偏好,对 ATAAD 的主动脉根部进行个体化处理。

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