Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Section of Vascular Surgery, Department of Surgery, Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.
Ann Thorac Surg. 2020 Jul;110(1):136-143. doi: 10.1016/j.athoracsur.2019.10.014. Epub 2019 Nov 26.
This study evaluated the short- and middle-term outcomes of different aortic root managements in the setting of acute type A aortic dissection (ATAAD): aortic root repair (ARR group), untouched aortic root (UAR group), and Bentall procedure (Bentall group).
The study enrolled 673 patients (512 men; age 48.8 ± 11.2 years) between 2010 and 2015. Survival, aortic growth, reintervention, and valve function were compared between the 3 groups.
The ages were 50.6 ± 9.9, 49.8 ± 12.2, and 44.0 ± 12.0 years for ARR, UAR, and Bentall groups, respectively (P < .01). The mean follow-up time was 3.0 years (range, 0.5-6.8 years). The aortic root diameters in the groups were 39.0 ± 5.1 mm in ARR, 38.2 ± 4.4 mm in UAR, and 50.3 ± 6.2 mm in Bentall (P < .01). The overall 30-day mortality was 11.7% (79 of 673). There was no difference in 30-day mortality between the 3 groups (P = .58). The estimated aortic root growth rate was 0.60 ± 0.17 mm/y for ARR and 0.50 ± 0.14 mm/y for UAR. During follow-up, 28 patients (4.1%) died. Differences in 5-year survival between the 3 groups did not reach statistical significance (P = .82). Aortic insufficiency greater than grade 2+ developed in 15 patients (2.2%). There was no significant difference between ARR and UAR in freedom from aortic insufficiency greater than grade 2+ (P = .56). None of the patients experienced new dissection or underwent proximal reoperation during the follow-up period.
Conservative techniques (ARR and UAR) and aggressive root replacement can both be performed with excellent short- and middle-term outcomes in ATAAD. Thus, an individualized approach in managing the aortic root for ATAAD is recommended based on the patient's general condition, root pathology, and the surgeon's preference.
本研究评估了急性 A 型主动脉夹层(ATAAD)患者中不同主动脉根部处理方法的短期和中期结果:主动脉根部修复(ARR 组)、未处理的主动脉根部(UAR 组)和 Bentall 手术(Bentall 组)。
本研究纳入了 2010 年至 2015 年间的 673 例患者(512 例男性;年龄 48.8 ± 11.2 岁)。比较三组之间的生存、主动脉生长、再次介入和瓣膜功能。
ARR、UAR 和 Bentall 组的年龄分别为 50.6 ± 9.9、49.8 ± 12.2 和 44.0 ± 12.0 岁(P<.01)。平均随访时间为 3.0 年(0.5-6.8 年)。ARR、UAR 和 Bentall 组的主动脉根部直径分别为 39.0 ± 5.1、38.2 ± 4.4 和 50.3 ± 6.2(P<.01)。总的 30 天死亡率为 11.7%(673 例中的 79 例)。三组之间 30 天死亡率无差异(P=.58)。估计的主动脉根部生长速度为 ARR 组 0.60 ± 0.17mm/y,UAR 组 0.50 ± 0.14mm/y。随访期间,28 例患者(4.1%)死亡。三组之间 5 年生存率无显著差异(P=.82)。15 例(2.2%)患者发生 2 级以上主动脉瓣关闭不全。ARR 和 UAR 之间 2 级以上主动脉瓣关闭不全无显著差异(P=.56)。随访期间无患者发生新发夹层或近端再手术。
在 ATAAD 中,保守技术(ARR 和 UAR)和积极的根部置换均可获得极好的短期和中期结果。因此,建议根据患者的一般情况、根部病变和外科医生的偏好,对 ATAAD 的主动脉根部进行个体化处理。