Ernst C B, Elliott J P, Ryan C J, Abu-Hamad G, Tilley B C, Murphy R K, Smith R F, Reddy D J, Szilagyi D E
Division of Vascular Surgery, Henry Ford Hospital, Detroit, MI 48202.
Ann Surg. 1988 Oct;208(4):401-9. doi: 10.1097/00000658-198810000-00002.
Of the 1771 patients who underwent aortofemoral bypass grafting (AFB) during the 30-year period of 1957-1986, 43 noninfected recurrent femoral anastomotic aneurysms (RFAA) developed in 28 patients. Thirty-six RFAAs were treated surgically, with one death and no amputations occurring. Seven small RFAAs (less than 2.0 cm) were treated expectantly without complications. Using univariate and multivariate analyses, clinical characteristics and other factors influencing results in patients with RFAAs were compared to two control groups: patients who had undergone AFB without the development of femoral anastomotic aneurysms (FAAs) and patients who had undergone FAA repairs but without recurrence of FAA. Comparative analyses suggested: 1) local wound complications after initial AFB or FAA repair increased risk of a RFAA (p less than 0.03); 2) development of an FAA within 4.5 years after AFB increased risk of a RFAA (p less than 0.0002); 3) following an FAA repair, risk of a RFAA was almost three times greater for women than for men (p less than 0.05); and 4) patients with arteriosclerotic heart disease (ASHD) were less likely to develop RFAA than those without ASHD (p less than 0.05). Among the 20 additional variables analyzed--including hypertension, smoking, diabetes mellitus, and etiology of primary vascular disease--no statistically significant influence on the development of RFAAs could be detected.
在1957年至1986年这30年期间接受主股动脉搭桥术(AFB)的1771例患者中,28例患者出现了43例非感染性复发性股动脉吻合口动脉瘤(RFAA)。36例RFAA接受了手术治疗,有1例死亡,未发生截肢情况。7例小型RFAA(直径小于2.0 cm)采取了观察等待的治疗方式,未出现并发症。通过单因素和多因素分析,将RFAA患者的临床特征及其他影响治疗结果的因素与两个对照组进行了比较:一组是接受了AFB但未发生股动脉吻合口动脉瘤(FAA)的患者,另一组是接受了FAA修复但未出现FAA复发的患者。比较分析表明:1)初次AFB或FAA修复术后的局部伤口并发症会增加RFAA的发生风险(p<0.03);2)AFB术后4.5年内发生FAA会增加RFAA的发生风险(p<0.0002);3)FAA修复术后,女性发生RFAA的风险几乎是男性的三倍(p<0.05);4)患有动脉硬化性心脏病(ASHD)的患者发生RFAA的可能性低于未患ASHD的患者(p<0.05)。在分析的另外20个变量中,包括高血压、吸烟、糖尿病和原发性血管疾病的病因,均未发现对RFAA的发生有统计学上的显著影响。