Berg R D, Wommack E, Deitch E A
Department of Microbiology and Immunology, Louisiana State University Medical Center, Shreveport, LA 71130.
Arch Surg. 1988 Nov;123(11):1359-64. doi: 10.1001/archsurg.1988.01400350073011.
Gram-negative, enteric bacilli of the indigenous gastrointestinal tract microflora translocated primarily to the mesenteric lymph nodes in mice given either oral penicillin G sodium or clindamycin hydrochloride. These bacteria also translocated to the mesenteric lymph nodes in mice injected with cyclophosphamide or prednisone. However, in mice treated with the combination of an oral antibiotic plus an immunosuppressive drug, the translocating bacteria spread systemically to the peritoneal cavity. When the treatment with clindamycin and prednisone was extended to 12 days, the mice died of lethal sepsis beginning eight days after treatment. Thus, the combination of intestinal bacterial overgrowth and host immunosuppression synergistically promoted bacterial translocation from the gastrointestinal tract that resulted in lethal sepsis.
革兰氏阴性的肠道固有微生物群中的肠杆菌，在给予口服青霉素G钠或盐酸克林霉素的小鼠中主要易位至肠系膜淋巴结。这些细菌在注射环磷酰胺或泼尼松的小鼠中也易位至肠系膜淋巴结。然而，在用口服抗生素加免疫抑制药物联合治疗的小鼠中，易位细菌全身扩散至腹腔。当克林霉素和泼尼松的治疗延长至12天时，小鼠在治疗后8天开始死于致死性败血症。因此，肠道细菌过度生长与宿主免疫抑制的联合作用协同促进了细菌从胃肠道的易位，从而导致致死性败血症。
