Steffen E K, Berg R D, Deitch E A
Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri-Columbia.
J Infect Dis. 1988 May;157(5):1032-8. doi: 10.1093/infdis/157.5.1032.
Bacterial translocation is defined as the passage of indigenous bacteria from the gastrointestinal (GI) tract through the lamina propria to the mesenteric lymph nodes (MLN) and other organs. We compared the relative abilities of various aerobic, facultatively anaerobic, and obligately anaerobic bacteria to translocate from the GI tract to the MLN in gnotobiotic mice colonized with single strains of bacteria. Indigenous gram-negative enteric bacilli translocated in large numbers to the MLN, whereas gram-positive bacteria translocated at intermediate levels and obligately anaerobic bacteria at only very low levels. Our results suggest that enteric bacilli such as Escherichia coli, Proteus, and Enterobacter are associated with a higher incidence of bacteremia in debilitated patients, because these bacteria translocate more efficiently from the GI tract than do other bacteria, especially obligate anaerobes.
细菌易位被定义为肠道内的固有细菌穿过固有层进入肠系膜淋巴结（MLN）和其他器官的过程。我们比较了各种需氧菌、兼性厌氧菌和专性厌氧菌从胃肠道易位至无菌小鼠肠系膜淋巴结的相对能力，这些无菌小鼠定殖有单一菌株的细菌。肠道固有革兰氏阴性杆菌大量易位至肠系膜淋巴结，而革兰氏阳性菌以中等水平易位，专性厌氧菌仅以极低水平易位。我们的结果表明，诸如大肠杆菌、变形杆菌和肠杆菌等肠道杆菌与虚弱患者中较高的菌血症发生率相关，因为这些细菌比其他细菌，尤其是专性厌氧菌，能更有效地从胃肠道易位。
