Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore-46, Tamil Nadu, India; Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, Republic of Korea.
Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore-46, Tamil Nadu, India; EuroEspes Biomedical Research Centre, Institute of Medical Science and Genomic Medicine, Coruna, Spain.
J Infect Public Health. 2020 Apr;13(4):527-531. doi: 10.1016/j.jiph.2019.10.005. Epub 2019 Nov 27.
The present investigation of genotoxicity of lead (Pb) among workers exposed to inorganic Pb environment, which appears to be first of its kind in South India, was undertaken to assess the seriousness, the ill effects of health contributed by this serious environmental pollutant.
A total of 144 samples comprising of exposed (n=72), and control (n=72) subjects were screened. Demographic data and their associated health levels were undertaken by means of a questionnaire. The blood samples collected were subjected to chromosomal analysis, micronuclei assessment and comet assay.
A higher level of Pb was quantified in the blood samples of all exposed subjects. An overview of the genotoxic assessment helped us understand parameters such as age do not affect or bring about any difference in the genotoxic potential of the exposed and control subjects. The only signification feature that resulted in an enhanced genotoxic potential was the years of exposure to the Pb environment that accumulated the dosage of Pb over the years.
The high positivity of genotoxic potential of Pb in a country like India highlights the need for labelling hazardous metals in paint containers as a means to assure strict regulations.
本研究是针对印度南部首次开展的职业性无机铅暴露工人的遗传毒性研究，旨在评估这一严重环境污染物的严重程度及其对健康的不良影响。
共纳入 144 例研究对象，其中暴露组 72 例，对照组 72 例。通过问卷调查收集研究对象的人口统计学数据和健康状况。采集血样进行染色体分析、微核检测和彗星试验。
所有暴露组的血铅水平均升高。遗传毒性评估的结果表明，年龄因素对暴露组和对照组的遗传毒性无影响或差异无统计学意义。唯一导致遗传毒性增强的显著特征是暴露于 Pb 环境的年限，这导致了体内铅蓄积量的增加。
在印度这样的国家，Pb 具有高度的遗传毒性，这凸显了在油漆容器上标注危险金属的必要性，以确保严格的监管。
