Ma Ling-Zhi, Huang Yu-Yuan, Wang Zuo-Teng, Li Jie-Qiong, Hou Xiao-He, Shen Xue-Ning, Ou Ya-Nan, Dong Qiang, Tan Lan, Yu Jin-Tai, Initiative Alzheimer's Disease Neuroimaging
Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Aging (Albany NY). 2019 Dec 2;11(23):10939-10951. doi: 10.18632/aging.102496.
A subgroup of overweight/obese individuals, who had favorable metabolic profiles, was termed as metabolically healthy overweight/obese (MHO). Several studies suggested that MHO individuals were not at increased risk of cardiovascular disease and all-course mortality. However, whether MHO is associated with excess risk of Alzheimer's disease (AD) in elders remains unclear. To explore the risk of AD among MHO phenotype and investigate whether MHO associates with neurodegenerative biomarkers of AD, we assessed body mass index-metabolic status phenotypes of 1199 longitudinal elders from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort using the Adult Treatment Panel-III (ATP- III) criteria. MHO subjects were at a significantly decreased risk for AD (adjusted HR=0.73, 95% CI: 0.54-0.97) compared with metabolically healthy normal weight (MHNW) subjects. In multivariable linear regression models, the cross-sectional associations of MHO with cerebrospinal fluid (CSF) biomarkers, brain Aβ load, and cortical structure were explored. MHO was positively correlated with CSF-Aβ (β=0.746, P=0.015), hippocampal volume (β=0.181, P=0.011), and whole brain volume (β=0.133, P=0.004). The MHO phenotype of the elder conferred a decreased risk of AD and its role may be driven by Aβ.
一组具有良好代谢特征的超重/肥胖个体被称为代谢健康的超重/肥胖者（MHO）。多项研究表明，MHO个体患心血管疾病和全因死亡率的风险并未增加。然而，MHO是否与老年人患阿尔茨海默病（AD）的额外风险相关仍不清楚。为了探讨MHO表型个体患AD的风险，并研究MHO是否与AD的神经退行性生物标志物相关，我们使用成人治疗小组III（ATP-III）标准，对来自阿尔茨海默病神经影像学倡议（ADNI）队列的1199名纵向研究的老年人的体重指数-代谢状态表型进行了评估。与代谢健康的正常体重（MHNW）个体相比，MHO个体患AD的风险显著降低（校正风险比=0.73，95%置信区间：0.54-0.97）。在多变量线性回归模型中，探讨了MHO与脑脊液（CSF）生物标志物、脑淀粉样蛋白负荷和皮质结构的横断面关联。MHO与CSF-Aβ（β=0.746，P=0.015）、海马体积（β=0.181，P=0.011）和全脑体积（β=0.133，P=0.004）呈正相关。老年人的MHO表型降低了患AD的风险，其作用可能由淀粉样蛋白驱动。
