Department of Chemistry, Scripps Research, La Jolla, California 92037, United States.
Chem Rev. 2020 Jun 10;120(11):4831-4847. doi: 10.1021/acs.chemrev.9b00557. Epub 2019 Dec 4.
Autocatalytic models for the emergence of homochirality have been of interest for more than half a century. The sole experimental example of such an amplifying autocatalytic reaction is the Soai reaction. In this review, we trace the history of the theoretical models and the experimental work that led up to the discovery of the remarkable, singular Soai reaction. The experimental and computational studies that have helped to delineate the mechanism of this reaction are discussed in detail. Studies of both the concept of chiral symmetry breaking as well as the subsequent chiral amplification process are discussed. Particular attention is paid to flaws in some of the published models, and suggestions are offered for how such issues might be avoided in future work. The outlook in the search for a prebiotically plausible version of such an amplifying autocatalytic system is presented.
半个多世纪以来，手性自发产生的自动催化模型一直备受关注。这种放大的自动催化反应的唯一实验范例是 Soai 反应。在这篇综述中，我们追溯了导致这一显著而独特的 Soai 反应发现的理论模型和实验工作的历史。详细讨论了有助于阐明该反应机制的实验和计算研究。讨论了手性对称破缺的概念以及随后的手性放大过程。特别关注了一些已发表模型中的缺陷，并就如何避免未来工作中的此类问题提出了建议。提出了在手生性合理的情况下寻找这种放大自动催化系统的前景。
