Mishra Madan, Singh Gaurav, Gaur Amit, Tewari Abhivyakti
Department of Oral and Maxillofacial Surgery, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.
Natl J Maxillofac Surg. 2019 Jul-Dec;10(2):232-234. doi: 10.4103/njms.NJMS_24_19. Epub 2019 Nov 12.
Stevens-Johnson syndrome (SJS) is a severe form of erythema multiforme, is a self-limiting acute inflammatory disease of multifactorial origin, but can also present as a chronic recurrent lesion. It causes a whole plethora of lesions, mostly mucocutaneous. It is a dermatologic emergency that occurs with a spectrum of severity and can result in severe morbidity and mortality. Lip adhesion is an unusual complication of healing in the lesions of SJS, for which only a few cases have been reported till date which not only causes esthetic morbidity but also impairs the proper functioning of the patient. The importance of this lesion also lies in its multifactorial and varied origin, this being the first case to report azithromycin as a causative drug, leading to SJS associated with lip adhesion. In this paper, we present a case report of SJS with lip adhesion, azithromycin being the causative drug, which was treated surgically with chalinoplasty. Along with it, the clinical features, its pathogenesis, the preventive measures, and the treatment modalities for the same including conservative as well as surgical have also been extensively discussed with a review of the existing English literature to date.
史蒂文斯 - 约翰逊综合征（SJS）是多形红斑的一种严重形式，是一种多因素起源的自限性急性炎症性疾病，但也可表现为慢性复发性病变。它会引发大量病变，主要是皮肤黏膜病变。这是一种皮肤科急症，其严重程度不一，可导致严重的发病率和死亡率。唇部粘连是SJS病变愈合过程中一种不常见的并发症，迄今为止仅有少数病例报道，它不仅会造成美观问题，还会影响患者的正常功能。这种病变的重要性还在于其多因素且多样的起源，这是首例报告阿奇霉素作为致病药物导致SJS并伴有唇部粘连的病例。在本文中，我们呈现了一例由阿奇霉素作为致病药物引起的伴有唇部粘连的SJS病例报告，该病例通过唇成形术进行了手术治疗。同时，还结合对现有英文文献的回顾，广泛讨论了其临床特征、发病机制、预防措施以及包括保守治疗和手术治疗在内的治疗方式。
