Ph.D. Program for Aging, China Medical University, Taichung, Taiwan.
Department of Electrical and Computer Engineering, Institute of Electrical Control Engineering, National Chiao Tung University, Hsinchu, Taiwan.
PLoS One. 2019 Dec 4;14(12):e0225363. doi: 10.1371/journal.pone.0225363. eCollection 2019.
Exposure to air pollutants is known to have adverse effects on human health; however, little is known about the association between hydrocarbons in air and an ischemic stroke (IS) event. We investigated whether long-term exposure to airborne hydrocarbons, including volatile organic compounds, increased IS risk. This retrospective cohort study included 283,666 people aged 40 years or older in Taiwan. Cox proportional hazards regression analysis was used to fit single- and multiple-pollutant models for two targeted pollutants, total hydrocarbons (THC) and nonmethane hydrocarbons (NMHC), and estimated the risk of IS. Before controlling for multiple pollutants, hazard ratios (HRs) of IS with 95% confidence intervals for the overall population were 2.69 (2.64-2.74) at 0.16-ppm increase in THC and 1.62 (1.59-1.66) at 0.11-ppm increase in NMHC. For the multiple-pollutant models controlling for PM2.5, the adjusted HR was 3.64 (3.56-3.72) for THC and 2.21 (2.16-2.26) for NMHC. Our findings suggest that long-term exposure to THC and NMHC may be a risk factor for IS development.
已知暴露于空气污染物对人类健康有不良影响；然而，对于空气中的碳氢化合物与缺血性中风（IS）事件之间的关联知之甚少。我们研究了长期暴露于空气中的碳氢化合物，包括挥发性有机化合物，是否会增加 IS 风险。这项回顾性队列研究纳入了台湾 283666 名年龄在 40 岁或以上的人群。使用 Cox 比例风险回归分析拟合了两种靶向污染物（总碳氢化合物（THC）和非甲烷碳氢化合物（NMHC））的单污染物和多污染物模型，并估计了 IS 的风险。在不考虑多种污染物的情况下，THC 浓度每增加 0.16ppm，整体人群的 IS 风险比（HR）及其 95%置信区间为 2.69（2.64-2.74），NMHC 浓度每增加 0.11ppm，HR 为 1.62（1.59-1.66）。在多污染物模型中，PM2.5 校正后，THC 的调整 HR 为 3.64（3.56-3.72），NMHC 的调整 HR 为 2.21（2.16-2.26）。我们的研究结果表明，长期暴露于 THC 和 NMHC 可能是 IS 发展的一个危险因素。
