Institute for Hospital Management, Tsing Hua University, Shenzhen Campus, Shenzhen, China.
Hechi Third People's Hospital, Guangxi, China.
Ren Fail. 2019 Nov;41(1):1021-1027. doi: 10.1080/0886022X.2019.1679644.
The objective of this study was to assess whether an elderly patient's frailty was associated with acute kidney injury (AKI) and to examine whether severe frailty group had an increased risk of AKI than mild-moderate group. We searched The Cochrane Library, PubMed, and EMBASE for relevant studies without language limitations before 1 March 2019 with a priori defined inclusion and exclusion criteria. Five population-based cohort studies were included for systematic review and meta-analysis. Compared with the control group, the frailty group is significantly associated AKI (Odds Ratio = 2.05; 95% CI: 1.23-3.43). The moderate-severe frailty group has an increased risk of AKI than mild frailty group (Hazard Ratio = 2.87; 95% CI: 1.60-5.17. In conclusion, the available best evidence support an association between frailty and AKI among elder patients, thus relevant interventions should be taken among elderly under potential risk of AKI.
本研究旨在评估老年患者的虚弱是否与急性肾损伤（AKI）相关，并探讨严重虚弱组与轻度-中度虚弱组相比是否有更高的 AKI 风险。我们在 2019 年 3 月 1 日之前，对符合既定纳入和排除标准的 Cochrane 图书馆、PubMed 和 EMBASE 中的相关研究进行了无语言限制的检索。对五项基于人群的队列研究进行了系统综述和荟萃分析。与对照组相比，虚弱组与 AKI 显著相关（优势比=2.05；95%置信区间：1.23-3.43）。中度-重度虚弱组发生 AKI 的风险高于轻度虚弱组（危险比=2.87；95%置信区间：1.60-5.17）。总之，现有最佳证据支持老年患者中虚弱与 AKI 之间存在关联，因此应在有潜在 AKI 风险的老年人群中采取相关干预措施。
