Yanaka A, Muto H
Department of Gastroenterology, University of Tsukuba, Ibaraki, Japan.
Dig Dis Sci. 1988 Nov;33(11):1459-65. doi: 10.1007/BF01537003.
To clarify the contributive factors in the recurrence of duodenal ulcer, the present study was carried out on 65 male patients with active duodenal ulcers and 20 healthy male subjects. After having verified that the ulcer had healed, gastric acid secretory responses to graded doses of tetragastrin from 62.5 to 16,000 ng/kg/hr were investigated using a logarithmic transformation model. Several clinical features were also investigated. The patients were divided into three groups based on the later endoscopic follow-up study for two years. The early-recurrent group included 16 patients with recurrence occurring within three months. The late-recurrent group included 25 with recurrence occurring after three months. The nonrecurrent group included 24 patients without recurrences during the follow-up period. The 20 healthy male subjects were defined as a control group. The results were as follows: (1) Significant differences were not discerned either in basal and peak acid outputs between the three patients groups. (2) The ED50 value for tetragastrin was lower in the early-recurrent group than in the other three groups. (3) The early-recurrent group showed a higher percentage of smokers than the other patient groups. These results suggest that smoking and increased parietal cell responsiveness correlates strongly with duodenal ulcer recurrence.
为明确十二指肠溃疡复发的相关因素，本研究对65例男性活动性十二指肠溃疡患者和20例健康男性受试者进行了研究。在证实溃疡愈合后，采用对数转换模型研究了62.5至16,000 ng/kg/hr不同剂量的四肽胃泌素刺激后的胃酸分泌反应。还研究了一些临床特征。根据随后两年的内镜随访研究，将患者分为三组。早期复发组包括16例在三个月内复发的患者。晚期复发组包括25例在三个月后复发的患者。无复发组包括24例在随访期间未复发的患者。20例健康男性受试者被定义为对照组。结果如下：（1）三组患者的基础胃酸分泌量和高峰胃酸分泌量均无显著差异。（2）早期复发组四肽胃泌素的半数有效剂量（ED50）值低于其他三组。（3）早期复发组吸烟者的比例高于其他患者组。这些结果表明，吸烟和壁细胞反应性增加与十二指肠溃疡复发密切相关。
