Aly A, Emås S
Digestion. 1982;25(2):88-95. doi: 10.1159/000198816.
The acid and pepsin responses to increasing doses of i.v. pentagastrin (0.01, 0.02, 0.1, 2.0 and 8.0 micrograms X kg-1 X h-1) were determined by gastric aspiration in 15 male duodenal ulcer (DU) patients and 11 male age-matched healthy controls (C). The lowest dose was infused for 60 min, the doses were then increased every 45 min. The stomach was continuously perfused with saline. Phenol red as marker showed an average loss of 8.4 +/- 1.4% in the DU and 10.0 +/- 1.4% in the C. Basal acid secretion and the dose-response (DR) curve for acid output (corrected for basal) did not differ for DU and C. The dose (D50) producing half the observed maximal acid response (MR), the calculated MR and calculated D50 was the same in DU and C. Similar results were obtained for pepsin secretion. The ratio of pepsin to acid secretion did not differ for DU and C. It is concluded that the sensitivity of the oxyntic as well as the peptic cells do not differ in DU and C with similar secretory capacity.
通过胃抽吸法测定了15例男性十二指肠溃疡（DU）患者和11例年龄匹配的男性健康对照者（C）对静脉注射递增剂量的五肽胃泌素（0.01、0.02、0.1、2.0和8.0微克·千克⁻¹·小时⁻¹）的胃酸和胃蛋白酶反应。最低剂量输注60分钟，然后每45分钟增加剂量。胃持续用生理盐水灌注。作为标志物的酚红显示，DU组平均损失8.4±1.4%，C组平均损失10.0±1.4%。DU组和C组的基础胃酸分泌以及胃酸分泌量（校正基础值后的）剂量反应（DR）曲线无差异。在DU组和C组中，产生观察到的最大胃酸反应（MR）一半的剂量（D50）、计算出的MR和计算出的D50相同。胃蛋白酶分泌也得到了类似结果。DU组和C组胃蛋白酶与胃酸分泌的比值无差异。结论是，DU组和C组壁细胞以及主细胞的敏感性无差异，分泌能力相似。
