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本文引用的文献

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Extracellular Vesicles (EVs) from Lung Adenocarcinoma Cells Promote Human Umbilical Vein Endothelial Cell (HUVEC) Angiogenesis through Yes Kinase-associated Protein (YAP) Transport.肺腺癌细胞来源的细胞外囊泡通过 Yes 相关蛋白激酶（YAP）转运促进人脐静脉内皮细胞（HUVEC）血管生成。
Int J Biol Sci. 2019 Aug 7;15(10):2110-2118. doi: 10.7150/ijbs.31605. eCollection 2019.
2
GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis.GEPIA2：一个用于大规模表达谱分析和交互式分析的增强型网络服务器。
Nucleic Acids Res. 2019 Jul 2;47(W1):W556-W560. doi: 10.1093/nar/gkz430.
3
Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats.人脐带间充质干细胞来源的细胞外囊泡促进大鼠坐骨神经横断后神经再生。
J Cell Mol Med. 2019 Apr;23(4):2822-2835. doi: 10.1111/jcmm.14190. Epub 2019 Feb 17.
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Exosomes derived from siRNA against GRP78 modified bone-marrow-derived mesenchymal stem cells suppress Sorafenib resistance in hepatocellular carcinoma.载有针对 GRP78 的 siRNA 的外泌体修饰的骨髓间充质干细胞可抑制肝癌对索拉非尼的耐药性。
J Nanobiotechnology. 2018 Dec 20;16(1):103. doi: 10.1186/s12951-018-0429-z.
5
YAP1-induced MALAT1 promotes epithelial-mesenchymal transition and angiogenesis by sponging miR-126-5p in colorectal cancer.YAP1 诱导的 MALAT1 通过海绵吸附 miR-126-5p 促进结直肠癌细胞的上皮-间充质转化和血管生成。
Oncogene. 2019 Apr;38(14):2627-2644. doi: 10.1038/s41388-018-0628-y. Epub 2018 Dec 10.
6
Long non-coding RNA H19 confers 5-Fu resistance in colorectal cancer by promoting SIRT1-mediated autophagy.长链非编码 RNA H19 通过促进 SIRT1 介导的自噬赋予结直肠癌对 5-Fu 的耐药性。
Cell Death Dis. 2018 Nov 19;9(12):1149. doi: 10.1038/s41419-018-1187-4.
7
Exosome-transmitted long non-coding RNA PTENP1 suppresses bladder cancer progression.外泌体传递的长非编码 RNA PTENP1 抑制膀胱癌进展。
Mol Cancer. 2018 Oct 3;17(1):143. doi: 10.1186/s12943-018-0880-3.
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LncRNA UCA1, Upregulated in CRC Biopsies and Downregulated in Serum Exosomes, Controls mRNA Expression by RNA-RNA Interactions.长链非编码RNA UCA1在结直肠癌活检组织中上调而在血清外泌体中下调，通过RNA-RNA相互作用控制mRNA表达。
Mol Ther Nucleic Acids. 2018 Sep 7;12:229-241. doi: 10.1016/j.omtn.2018.05.009. Epub 2018 Jun 2.
9
Screening key long non-coding RNAs in early-stage colon adenocarcinoma by RNA-sequencing.通过 RNA 测序筛选早期结肠腺癌中的关键长非编码 RNA。
Epigenomics. 2018 Sep;10(9):1215-1228. doi: 10.2217/epi-2017-0155. Epub 2018 Sep 5.
10
Long non-coding RNA SNHG15 interacts with and stabilizes transcription factor Slug and promotes colon cancer progression.长链非编码 RNA SNHG15 与转录因子 Slug 相互作用并稳定其表达，促进结肠癌的进展。
Cancer Lett. 2018 Jul 1;425:78-87. doi: 10.1016/j.canlet.2018.03.038. Epub 2018 Mar 29.

用针对ELFN1-AS1的小干扰RNA（siRNA）处理的人脐带间充质干细胞分泌的细胞外囊泡可抑制结肠腺癌的增殖和迁移。

Extracellular vesicles from human umbilical cord mesenchymal stem cells treated with siRNA against ELFN1-AS1 suppress colon adenocarcinoma proliferation and migration.

作者信息

Dong Liyang, Ding Chao, Zheng Tingting, Pu Yanan, Liu Jiameng, Zhang Wenzhe, Xue Fei, Kang Ping, Ma Yongbin, Wang Xuefeng, Mao Chaoming

机构信息

Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University Zhenjiang 212000, Jiangsu, China.

State Key Lab of Reproductive Medicine, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Nanjing Medical University Nanjing 211166, Jiangsu, China.

出版信息

Am J Transl Res. 2019 Nov 15;11(11):6989-6999. eCollection 2019.

PMID:31814902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6895508/
Abstract

Recent evidence has shown that long noncoding RNAs (lncRNAs) play major roles in tumorigenesis and cancer progression. The cancer genome atlas program (TCGA) database was used to screen colon adenocarcinoma (COAD)-related differentially expressed lncRNAs, which revealed that lncRNA ELFN1-AS1 was highly expressed in COAD. This study aimed to explore the regulatory role of ELFN1-AS1 in COAD and construct a gene delivery system based on extracellular vesicles (EVs). We found that ELFN1-AS1 levels were obviously increased in COAD patients and COAD tumor cells. Knockdown of ELFN1-AS1 expression by siRNA inhibited COAD cell proliferation and migration. Moreover, silencing ELFN1-AS1 significantly reduced the activation of extracellular signal-regulated protein kinase (Erk), up-regulated the protein expression of E-cadherin and down-regulated vimentin. In addition, we treated human umbilical cord mesenchymal stem cells (hUCMSCs) with siRNA-ELFN1-AS1 and found that EVs from siRNA-ELFN1-AS1-treated hUCMSCs could inhibit COAD cell proliferation and migration . These findings suggested that ELFN1-AS1 could promote the progression of COAD and that hUCMSC-EVs might be an attractive vehicle for the clinical administration of lncRNA-specific siRNAs in patients with COAD.

摘要

最近的证据表明，长链非编码RNA（lncRNAs）在肿瘤发生和癌症进展中起主要作用。利用癌症基因组图谱计划（TCGA）数据库筛选与结肠腺癌（COAD）相关的差异表达lncRNAs，结果显示lncRNA ELFN1-AS1在COAD中高表达。本研究旨在探讨ELFN1-AS1在COAD中的调控作用，并构建基于细胞外囊泡（EVs）的基因递送系统。我们发现，COAD患者和COAD肿瘤细胞中ELFN1-AS1水平明显升高。通过小干扰RNA（siRNA）敲低ELFN1-AS1表达可抑制COAD细胞增殖和迁移。此外，沉默ELFN1-AS1可显著降低细胞外信号调节蛋白激酶（Erk）的激活，上调E-钙黏蛋白的蛋白表达并下调波形蛋白。另外，我们用siRNA-ELFN1-AS1处理人脐带间充质干细胞（hUCMSCs），发现来自经siRNA-ELFN1-AS1处理的hUCMSCs的EVs可抑制COAD细胞增殖和迁移。这些发现表明，ELFN1-AS1可促进COAD的进展，并且hUCMSC-EVs可能是COAD患者临床应用lncRNA特异性siRNAs的有吸引力的载体。