Naito Y, Yoshikawa T, Oyamada H, Tainaka K, Morita Y, Kogawa T, Sugino S, Kondo M
First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.
Gastroenterol Jpn. 1988 Aug;23(4):363-70. doi: 10.1007/BF02779203.
Among 3,501 individuals receiving endoscopic examination for the upper digestive tract, 41 were found to have esophageal candidiasis including 17 malignancies, 14 immunological disorders, 4 diabetes mellitus, 7 other underlying diseases and 7 apparently healthy subjects. The diagnosis was made either by brushing of the esophagus or by histological examination of the biopsied specimen. Systemic invasion of fungi was observed mainly in patients with malignancy involving the hematopoietic system, and most of them had been treated by corticosteroids, antibiotics or anticancer agents. Although complications associated with esophageal candidiasis are rare, it is emphasized that those patients with malignancy as well as impared immunity should be carefully examined for esophageal candidiasis, in order to prevent the fungi from developing invasive candidiasis. It should be noted that a few cases of gastric ulcer treated by H2 blocker revealed esophageal candidiasis, suggesting that decrease of gastric acidity might be one of the factors involved in this pathological condition.
在3501名接受上消化道内镜检查的个体中，发现41人患有食管念珠菌病，其中包括17例恶性肿瘤患者、14例免疫功能紊乱患者、4例糖尿病患者、7例患有其他基础疾病的患者以及7例看似健康的受试者。诊断通过食管刷检或活检标本的组织学检查做出。真菌的全身侵袭主要见于累及造血系统的恶性肿瘤患者，且他们大多数曾接受过皮质类固醇、抗生素或抗癌药物治疗。尽管与食管念珠菌病相关的并发症很少见，但需要强调的是，那些患有恶性肿瘤以及免疫力受损的患者应仔细检查是否患有食管念珠菌病，以防止真菌发展为侵袭性念珠菌病。应当注意的是，少数接受H2阻滞剂治疗的胃溃疡患者显示患有食管念珠菌病，这表明胃酸降低可能是参与这种病理状况的因素之一。
