Trier J S, Bjorkman D J
Am J Med. 1984 Oct 30;77(4D):39-43.
Gastrointestinal Candida infection is more prevalent than previously recognized. It is most often seen in patients with underlying impairment of the immune system but may also occur in apparently normal individuals. Esophageal involvement is most common, presenting with odynophagia, dysphagia, or bleeding. Gastric Candida infection may cause diffuse mucosal involvement or focal invasion of benign gastric ulcers. Intestinal candidiasis is uncommon and poorly characterized. The diagnosis is usually established by visualizing the characteristic yeast or mycelial forms in endoscopic brushings and biopsies. Oral nystatin is effective therapy in many patients, but other antifungal agents may be needed in extensive or persistent disease, especially in immunocompromised patients.
胃肠道念珠菌感染比之前认为的更为普遍。它最常见于免疫系统存在潜在损害的患者，但也可能发生在看似正常的个体中。食管受累最为常见，表现为吞咽痛、吞咽困难或出血。胃念珠菌感染可能导致弥漫性黏膜受累或良性胃溃疡的局灶性侵袭。肠道念珠菌病并不常见，且特征描述较少。诊断通常通过在内镜刷检和活检中观察到特征性的酵母或菌丝形态来确立。口服制霉菌素对许多患者是有效的治疗方法，但对于广泛或持续性疾病，尤其是免疫功能低下的患者，可能需要使用其他抗真菌药物。
