抗体特异性有限会影响转录组分析。
Limited antibody specificity compromises epitranscriptomic analyses.
机构信息
Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, Staudingerweg 5, 55128, Mainz, Germany.
Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany.
出版信息
Nat Commun. 2019 Dec 11;10(1):5669. doi: 10.1038/s41467-019-13684-3.
Abstract
A controversial discussion on the occurrence of the RNA modification mA in mRNA takes a new turn, as an antibody with a central role in modification mapping was shown to also bind mRNA cap structures.
摘要
关于 mRNA 中 RNA 修饰 mA 发生的争议性讨论出现了新的转折，因为在修饰图谱中起核心作用的一种抗体也被证明可以结合 mRNA 帽结构。
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