Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 300052, Tianjin, China.
Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China.
Mol Psychiatry. 2020 Mar;25(3):517-529. doi: 10.1038/s41380-019-0627-6. Epub 2019 Dec 11.
The Chinese Imaging Genetics (CHIMGEN) study establishes the largest Chinese neuroimaging genetics cohort and aims to identify genetic and environmental factors and their interactions that are associated with neuroimaging and behavioral phenotypes. This study prospectively collected genomic, neuroimaging, environmental, and behavioral data from more than 7000 healthy Chinese Han participants aged 18-30 years. As a pioneer of large-sample neuroimaging genetics cohorts of non-Caucasian populations, this cohort can provide new insights into ethnic differences in genetic-neuroimaging associations by being compared with Caucasian cohorts. In addition to micro-environmental measurements, this study also collects hundreds of quantitative macro-environmental measurements from remote sensing and national survey databases based on the locations of each participant from birth to present, which will facilitate discoveries of new environmental factors associated with neuroimaging phenotypes. With lifespan environmental measurements, this study can also provide insights on the macro-environmental exposures that affect the human brain as well as their timing and mechanisms of action.
中国影像遗传学（CHIMGEN）研究建立了最大的中国神经影像遗传学队列，旨在确定与神经影像学和行为表型相关的遗传和环境因素及其相互作用。该研究前瞻性地从 7000 多名年龄在 18-30 岁的健康汉族中国参与者中收集了基因组、神经影像学、环境和行为数据。作为非白种人群体的大型神经影像遗传学队列的先驱，该队列可以通过与白种人群体进行比较，为遗传-神经影像关联中的种族差异提供新的见解。除了微观环境测量，该研究还从出生到现在每个参与者的位置，基于遥感和国家调查数据库，收集了数百个定量的宏观环境测量值，这将有助于发现与神经影像学表型相关的新环境因素。通过寿命期环境测量，该研究还可以提供有关影响大脑的宏观环境暴露及其作用时间和机制的见解。
