Li Ming, Liu Jianheng, Cui Xiang, Sun Guofei, Hu Jianwei, Xu Sijia, Yang Fei, Zhang Licheng, Wang Xiumei, Tang Peifu
Department of Orthopaedics, Chinese PLA General Hospital, Beijing 100853, China.
Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Regen Biomater. 2019 Dec;6(6):373-381. doi: 10.1093/rb/rbz019. Epub 2019 May 29.
The treatment of bone defect after bone tumor resection is a great challenge for orthopedic surgeons. It should consider that not only to inhibit tumor growth and recurrence, but also to repair the defect and preserve the limb function. Hence, it is necessary to find an ideal functional biomaterial that can repair bone defects and inactivate tumor. Magnetic nanoparticles (MNPs) have its unique advantages to achieve targeted hyperthermia to avoid damage to surrounding normal tissues and promote osteoblastic activity and bone formation. Based on the previous stage, we successfully prepared hydroxyapatite (HAP) composite poly(lactic-co-glycolic acid) (PLGA) scaffolds and verified its good osteogenic properties, in this study, we produced an HAP composite PLGA scaffolds modified with MNPs. The composite scaffold showed appropriate porosity and mechanical characteristics, while MNPs possessed excellent magnetic and thermal properties. The cytological assay indicated that the MNPs have antitumor ability and the composite scaffold possessed good biocompatibility. bone defect repair experiment revealed that the composite scaffold had good osteogenic capacity. Hence, we could demonstrate that the composite scaffolds have a good effect in bone repair, which could provide a potential approach for repairing bone defect after bone tumor excision.
骨肿瘤切除术后骨缺损的治疗对骨科医生来说是一项巨大挑战。这不仅要考虑抑制肿瘤生长和复发，还要修复缺损并保留肢体功能。因此，有必要找到一种理想的功能性生物材料，既能修复骨缺损又能使肿瘤失活。磁性纳米颗粒（MNPs）具有独特优势，可实现靶向热疗，避免对周围正常组织造成损伤，并促进成骨细胞活性和骨形成。基于前期工作，我们成功制备了羟基磷灰石（HAP）复合聚乳酸-羟基乙酸共聚物（PLGA）支架并验证了其良好的成骨性能，在本研究中，我们制备了用MNPs修饰的HAP复合PLGA支架。复合支架显示出合适的孔隙率和力学特性，而MNPs具有优异的磁性和热性能。细胞学分析表明MNPs具有抗肿瘤能力，复合支架具有良好的生物相容性。骨缺损修复实验表明复合支架具有良好的成骨能力。因此，我们可以证明复合支架在骨修复方面有良好效果，这可为骨肿瘤切除术后骨缺损的修复提供一种潜在方法。
