将针对立氏立克次体的特异性单克隆抗体添加到立克次体诊断检测组中。
Addition of monoclonal antibodies specific for Rickettsia akari to the rickettsial diagnostic panel.
作者信息
McDade J E, Black C M, Roumillat L F, Redus M A, Spruill C L
机构信息
Division of Viral Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
出版信息
J Clin Microbiol. 1988 Oct;26(10):2221-3. doi: 10.1128/jcm.26.10.2221-2223.1988.
Abstract
Monoclonal antibodies were produced from mice infected with Rickettsia akari (the etiologic agent of rickettsialpox) and evaluated for specificity in indirect fluorescent-antibody tests with 23 different rickettsial antigens. Of the nine antibodies that were evaluated, two were specific for R. akari and four reacted with R. akari and all other spotted fever group rickettsiae. The remaining three antibodies reacted with some, but not all, members of the spotted fever group. None of the antibodies reacted with typhus, scrub typhus, trench fever, or Q fever rickettsiae. Adding these antibodies to the list of available diagnostic reagents will facilitate identification of rickettsial diseases, particularly those caused by members of the spotted fever group, where the clinical presentations are similar and the etiologic agents are closely related antigenically.
摘要
用感染了小蛛立克次体（立克次体痘的病原体）的小鼠制备单克隆抗体，并在间接荧光抗体试验中用23种不同的立克次体抗原评估其特异性。在评估的9种抗体中，2种对小蛛立克次体具有特异性，4种与小蛛立克次体以及所有其他斑点热群立克次体发生反应。其余3种抗体与斑点热群的部分而非全部成员发生反应。没有一种抗体与斑疹伤寒、恙虫病、战壕热或Q热立克次体发生反应。将这些抗体添加到现有的诊断试剂列表中将有助于立克次体病的鉴定，特别是那些由斑点热群成员引起的疾病，因为这些疾病的临床表现相似且病原体在抗原上密切相关。
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